Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle

Jae Hyo Kim, Hee Young Kim, Kyungsoon Chung, Jin Chung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Acute ankle injuries are common problems and often lead to persistent pain. To investigate the underlying mechanism of ankle sprain pain, the response properties of spinal dorsal horn neurons were examined after ankle sprain. Acute ankle sprain was induced manually by overextending the ankle of a rat hindlimb in a direction of plantarflexion and inversion. The weightbearing ratio (WBR) of the affected foot was used as an indicator of pain. Single unit activities of dorsal horn neurons in response to plantarflexion and inversion of the foot or ankle compression were recorded from the medial part of the deep dorsal horn, laminae IV-VI, in normal and ankle-sprained rats. One day after ankle sprain, rats showed significantly reduced WBRs on the affected foot, and this reduction was partially restored by systemic morphine. The majority of deep dorsal horn neurons responded to a single ankle stimulus modality. After ankle sprain, the mean evoked response rates were significantly increased, and afterdischarges were developed in recorded dorsal horn neurons. The ankle sprain-induced enhanced evoked responses were significantly reduced by morphine, which was reversed by naltrexone. The data indicate that movement-specific dorsal horn neuron responses were enhanced after ankle sprain in a morphine-dependent manner, thus suggesting that hyperactivity of dorsal horn neurons is an underlying mechanism of pain after ankle sprain.

Original languageEnglish (US)
Pages (from-to)2043-2049
Number of pages7
JournalJournal of Neurophysiology
Volume105
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Posterior Horn Cells
Ankle Injuries
Ankle
Foot
Morphine
Pain
Naltrexone
Weight-Bearing
Hindlimb

Keywords

  • Acute ankle sprain
  • Dorsal horn neuron responses
  • Foot movements
  • Inflammatory pain
  • Morphine effect

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle. / Kim, Jae Hyo; Kim, Hee Young; Chung, Kyungsoon; Chung, Jin.

In: Journal of Neurophysiology, Vol. 105, No. 5, 05.2011, p. 2043-2049.

Research output: Contribution to journalArticle

Kim, Jae Hyo ; Kim, Hee Young ; Chung, Kyungsoon ; Chung, Jin. / Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle. In: Journal of Neurophysiology. 2011 ; Vol. 105, No. 5. pp. 2043-2049.
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