Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum

J. M. Yuhas, R. L. Ullrich

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The antitumor properties of Corynebacterium parvum have been studied in young (3 to 8 month old) and aged (18 of more months old) BALB/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25 to 33 month old) BALB/c mice bearing primary mammary tumors. These aged BALB/c mice were shown to be less immunoresponsive than their younger couterparts, and this, in combination with nonimmunological factors, made them more sensitive to the lethal effects of the line 1 carcinoma. Correspondingly, C. parvum proved to have less antitumor activity in aged mice than it did in young mice. In spite of this relatively weaker antitumor activity for C. parvum in aged mice, repeated injections of this agent were able to induce temporary regressions of the primary mammary tumors studied and thereby prolong survival time.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalCancer Research
Volume36
Issue number1
StatePublished - 1976
Externally publishedYes

Fingerprint

Propionibacterium acnes
Breast Neoplasms
Carcinoma
Transplants
Lung
Injections

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum. / Yuhas, J. M.; Ullrich, R. L.

In: Cancer Research, Vol. 36, No. 1, 1976, p. 161-166.

Research output: Contribution to journalArticle

Yuhas, J. M. ; Ullrich, R. L. / Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum. In: Cancer Research. 1976 ; Vol. 36, No. 1. pp. 161-166.
@article{ac1e65c79cbf42a0a690fd29b83d173b,
title = "Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum",
abstract = "The antitumor properties of Corynebacterium parvum have been studied in young (3 to 8 month old) and aged (18 of more months old) BALB/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25 to 33 month old) BALB/c mice bearing primary mammary tumors. These aged BALB/c mice were shown to be less immunoresponsive than their younger couterparts, and this, in combination with nonimmunological factors, made them more sensitive to the lethal effects of the line 1 carcinoma. Correspondingly, C. parvum proved to have less antitumor activity in aged mice than it did in young mice. In spite of this relatively weaker antitumor activity for C. parvum in aged mice, repeated injections of this agent were able to induce temporary regressions of the primary mammary tumors studied and thereby prolong survival time.",
author = "Yuhas, {J. M.} and Ullrich, {R. L.}",
year = "1976",
language = "English (US)",
volume = "36",
pages = "161--166",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "1",

}

TY - JOUR

T1 - Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum

AU - Yuhas, J. M.

AU - Ullrich, R. L.

PY - 1976

Y1 - 1976

N2 - The antitumor properties of Corynebacterium parvum have been studied in young (3 to 8 month old) and aged (18 of more months old) BALB/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25 to 33 month old) BALB/c mice bearing primary mammary tumors. These aged BALB/c mice were shown to be less immunoresponsive than their younger couterparts, and this, in combination with nonimmunological factors, made them more sensitive to the lethal effects of the line 1 carcinoma. Correspondingly, C. parvum proved to have less antitumor activity in aged mice than it did in young mice. In spite of this relatively weaker antitumor activity for C. parvum in aged mice, repeated injections of this agent were able to induce temporary regressions of the primary mammary tumors studied and thereby prolong survival time.

AB - The antitumor properties of Corynebacterium parvum have been studied in young (3 to 8 month old) and aged (18 of more months old) BALB/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25 to 33 month old) BALB/c mice bearing primary mammary tumors. These aged BALB/c mice were shown to be less immunoresponsive than their younger couterparts, and this, in combination with nonimmunological factors, made them more sensitive to the lethal effects of the line 1 carcinoma. Correspondingly, C. parvum proved to have less antitumor activity in aged mice than it did in young mice. In spite of this relatively weaker antitumor activity for C. parvum in aged mice, repeated injections of this agent were able to induce temporary regressions of the primary mammary tumors studied and thereby prolong survival time.

UR - http://www.scopus.com/inward/record.url?scp=0017233209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017233209&partnerID=8YFLogxK

M3 - Article

C2 - 1247995

AN - SCOPUS:0017233209

VL - 36

SP - 161

EP - 166

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 1

ER -