Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation

M. J. Müller, Sabine Loyal, M. Schwarze, J. Lobers, O. Selberg, B. Ringe, R. Pichlmayr

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Resting energy expenditure (REE), body composition, and the biochemical parameters of liver function were measured in 26 patients before and 432 days (range: 103-1022 days) after liver transplantation (LTX). PreLTX REE was variable (mean: 1638 +/- 308 kcal/day, range: 1220-2190 kcal/day or +10 +/- 11% of Harris Benedict = HB prediction, range: -19 - +33%) and was closely related to body cell mass (r = 0.66, p < 0.0003). PostLTX REE was variable (mean: 1612 +/- 358 kcal/day, range: 1010-2490 kcal/day or +5 +/- 15% of HB prediction, range: -20 - +37%) and was closely related to body cell mass (r = 0.65, p < 0.0006). When compared with preLTX values only small changes in mean REE (-71 +/- 43 kcal/day) and a close correlation between pre and postLTX REE (r = 0.82, p < 0.001) were observed. In contrast to REE, changes in body weight were highly variable (-16.5 - +32.7 kg/year). This variance was not explained by the number of postoperative complications, pre and postLTX liver function, possible graft rejection and/or hepatitis reinfection. Pre-operative hypermetabolism (i.e. REE >+20% of HB prediction) was associated with postoperative hypermetabolism and a reduced liver function before and after LTX. Hypermetabolic patients had a poorer nutritional outcome after LTX (weight change: 0 +/- 8.4 kg/year) when compared with normometabolic controls (weight change: +5.7 +/- 7.4 kg/year; p < 0.05). There was no significant association between deviations in pre and postLTX REE and changes in body weight. When corrected for changes in the nutritional state our data provide evidence for the persistence of resting energy expenditure in liver transplant patients.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalClinical Nutrition
Volume13
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Liver Cirrhosis
Liver Transplantation
Energy Metabolism
Liver
Weights and Measures
Body Weight Changes
Body Composition
Transplants

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)

Cite this

Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation. / Müller, M. J.; Loyal, Sabine; Schwarze, M.; Lobers, J.; Selberg, O.; Ringe, B.; Pichlmayr, R.

In: Clinical Nutrition, Vol. 13, No. 3, 1994, p. 145-152.

Research output: Contribution to journalArticle

Müller, MJ, Loyal, S, Schwarze, M, Lobers, J, Selberg, O, Ringe, B & Pichlmayr, R 1994, 'Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation', Clinical Nutrition, vol. 13, no. 3, pp. 145-152. https://doi.org/10.1016/0261-5614(94)90093-0
Müller, M. J. ; Loyal, Sabine ; Schwarze, M. ; Lobers, J. ; Selberg, O. ; Ringe, B. ; Pichlmayr, R. / Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation. In: Clinical Nutrition. 1994 ; Vol. 13, No. 3. pp. 145-152.
@article{9a142a4ea60b459eb51962c6a1bf5725,
title = "Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation",
abstract = "Resting energy expenditure (REE), body composition, and the biochemical parameters of liver function were measured in 26 patients before and 432 days (range: 103-1022 days) after liver transplantation (LTX). PreLTX REE was variable (mean: 1638 +/- 308 kcal/day, range: 1220-2190 kcal/day or +10 +/- 11{\%} of Harris Benedict = HB prediction, range: -19 - +33{\%}) and was closely related to body cell mass (r = 0.66, p < 0.0003). PostLTX REE was variable (mean: 1612 +/- 358 kcal/day, range: 1010-2490 kcal/day or +5 +/- 15{\%} of HB prediction, range: -20 - +37{\%}) and was closely related to body cell mass (r = 0.65, p < 0.0006). When compared with preLTX values only small changes in mean REE (-71 +/- 43 kcal/day) and a close correlation between pre and postLTX REE (r = 0.82, p < 0.001) were observed. In contrast to REE, changes in body weight were highly variable (-16.5 - +32.7 kg/year). This variance was not explained by the number of postoperative complications, pre and postLTX liver function, possible graft rejection and/or hepatitis reinfection. Pre-operative hypermetabolism (i.e. REE >+20{\%} of HB prediction) was associated with postoperative hypermetabolism and a reduced liver function before and after LTX. Hypermetabolic patients had a poorer nutritional outcome after LTX (weight change: 0 +/- 8.4 kg/year) when compared with normometabolic controls (weight change: +5.7 +/- 7.4 kg/year; p < 0.05). There was no significant association between deviations in pre and postLTX REE and changes in body weight. When corrected for changes in the nutritional state our data provide evidence for the persistence of resting energy expenditure in liver transplant patients.",
author = "M{\"u}ller, {M. J.} and Sabine Loyal and M. Schwarze and J. Lobers and O. Selberg and B. Ringe and R. Pichlmayr",
year = "1994",
doi = "10.1016/0261-5614(94)90093-0",
language = "English (US)",
volume = "13",
pages = "145--152",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "3",

}

TY - JOUR

T1 - Resting energy expenditure and nutritional state in patients with liver cirrhosis before and after liver transplantation

AU - Müller, M. J.

AU - Loyal, Sabine

AU - Schwarze, M.

AU - Lobers, J.

AU - Selberg, O.

AU - Ringe, B.

AU - Pichlmayr, R.

PY - 1994

Y1 - 1994

N2 - Resting energy expenditure (REE), body composition, and the biochemical parameters of liver function were measured in 26 patients before and 432 days (range: 103-1022 days) after liver transplantation (LTX). PreLTX REE was variable (mean: 1638 +/- 308 kcal/day, range: 1220-2190 kcal/day or +10 +/- 11% of Harris Benedict = HB prediction, range: -19 - +33%) and was closely related to body cell mass (r = 0.66, p < 0.0003). PostLTX REE was variable (mean: 1612 +/- 358 kcal/day, range: 1010-2490 kcal/day or +5 +/- 15% of HB prediction, range: -20 - +37%) and was closely related to body cell mass (r = 0.65, p < 0.0006). When compared with preLTX values only small changes in mean REE (-71 +/- 43 kcal/day) and a close correlation between pre and postLTX REE (r = 0.82, p < 0.001) were observed. In contrast to REE, changes in body weight were highly variable (-16.5 - +32.7 kg/year). This variance was not explained by the number of postoperative complications, pre and postLTX liver function, possible graft rejection and/or hepatitis reinfection. Pre-operative hypermetabolism (i.e. REE >+20% of HB prediction) was associated with postoperative hypermetabolism and a reduced liver function before and after LTX. Hypermetabolic patients had a poorer nutritional outcome after LTX (weight change: 0 +/- 8.4 kg/year) when compared with normometabolic controls (weight change: +5.7 +/- 7.4 kg/year; p < 0.05). There was no significant association between deviations in pre and postLTX REE and changes in body weight. When corrected for changes in the nutritional state our data provide evidence for the persistence of resting energy expenditure in liver transplant patients.

AB - Resting energy expenditure (REE), body composition, and the biochemical parameters of liver function were measured in 26 patients before and 432 days (range: 103-1022 days) after liver transplantation (LTX). PreLTX REE was variable (mean: 1638 +/- 308 kcal/day, range: 1220-2190 kcal/day or +10 +/- 11% of Harris Benedict = HB prediction, range: -19 - +33%) and was closely related to body cell mass (r = 0.66, p < 0.0003). PostLTX REE was variable (mean: 1612 +/- 358 kcal/day, range: 1010-2490 kcal/day or +5 +/- 15% of HB prediction, range: -20 - +37%) and was closely related to body cell mass (r = 0.65, p < 0.0006). When compared with preLTX values only small changes in mean REE (-71 +/- 43 kcal/day) and a close correlation between pre and postLTX REE (r = 0.82, p < 0.001) were observed. In contrast to REE, changes in body weight were highly variable (-16.5 - +32.7 kg/year). This variance was not explained by the number of postoperative complications, pre and postLTX liver function, possible graft rejection and/or hepatitis reinfection. Pre-operative hypermetabolism (i.e. REE >+20% of HB prediction) was associated with postoperative hypermetabolism and a reduced liver function before and after LTX. Hypermetabolic patients had a poorer nutritional outcome after LTX (weight change: 0 +/- 8.4 kg/year) when compared with normometabolic controls (weight change: +5.7 +/- 7.4 kg/year; p < 0.05). There was no significant association between deviations in pre and postLTX REE and changes in body weight. When corrected for changes in the nutritional state our data provide evidence for the persistence of resting energy expenditure in liver transplant patients.

UR - http://www.scopus.com/inward/record.url?scp=0028198752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028198752&partnerID=8YFLogxK

U2 - 10.1016/0261-5614(94)90093-0

DO - 10.1016/0261-5614(94)90093-0

M3 - Article

AN - SCOPUS:0028198752

VL - 13

SP - 145

EP - 152

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 3

ER -