Resting energy expenditure in severely burned children

Analysis of agreement between indirect calorimetry and prediction equations using the Bland-Altman method

Oscar Suman, Ronald P. Mlcak, David L. Chinkes, David Herndon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Introduction: Knowledge of a child's resting energy expenditure (REE) is essential in optimizing nutritional support for severely burned children. The provision of adequate nutritional support is vital in order to avoid the consequences of malnutrition or overfeeding. Nutritional requirements for severely burned children are often based on equations for estimates of REE. The accuracy of the predictive equations of REE has been questioned and many authors have advocated the measurement of REE. This study tests the hypothesis that estimates of REE vary significantly from measured REE (MREE) in a population of severely burned children, and are not accurate for determining nutritional requirements. Methods: In 91 severely burned children aged between 3 and 18 years, REE was measured by indirect calorimetry (MREE) at the height of the hypermetabolic response and compared with predicted equations (PREE) from the Food and Agriculture/World Health Organization/United Nations University (FAO/WHO/UNU), Schofield-HW and Harris-Benedict. Agreement between indirect calorimetry and predicted equations was assessed following the Bland-Altman method. Results: In the entire cohort group, predicted REE from all three equations were significantly lower compared to MREE (p < 0.05). There was poor agreement between the MREE and predicted using all three equations. The Schofield-HW equation showed the lowest mean MREE-PREE difference: 635 ± 526 kcal/day (limits of agreement -608 and 1878 kcal/day; 95% confidence interval for the bias 525-745 kcal/day). Additionally, all three equations under predicted REE and were not significantly different from one another (p = 0.98). Conclusions: Until more accurate predicted equations are developed, we recommend indirect calorimetry measurements for determining resting energy expenditure in severely burned children.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalBurns
Volume32
Issue number3
DOIs
StatePublished - May 2006

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Indirect Calorimetry
Energy Metabolism
Nutritional Requirements
Nutritional Support
United Nations
Agriculture
Malnutrition
Confidence Intervals
Food

Keywords

  • Burns
  • Pediatric
  • Predicted resting energy expenditure
  • Resting energy expenditure

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Resting energy expenditure in severely burned children : Analysis of agreement between indirect calorimetry and prediction equations using the Bland-Altman method. / Suman, Oscar; Mlcak, Ronald P.; Chinkes, David L.; Herndon, David.

In: Burns, Vol. 32, No. 3, 05.2006, p. 335-342.

Research output: Contribution to journalArticle

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abstract = "Introduction: Knowledge of a child's resting energy expenditure (REE) is essential in optimizing nutritional support for severely burned children. The provision of adequate nutritional support is vital in order to avoid the consequences of malnutrition or overfeeding. Nutritional requirements for severely burned children are often based on equations for estimates of REE. The accuracy of the predictive equations of REE has been questioned and many authors have advocated the measurement of REE. This study tests the hypothesis that estimates of REE vary significantly from measured REE (MREE) in a population of severely burned children, and are not accurate for determining nutritional requirements. Methods: In 91 severely burned children aged between 3 and 18 years, REE was measured by indirect calorimetry (MREE) at the height of the hypermetabolic response and compared with predicted equations (PREE) from the Food and Agriculture/World Health Organization/United Nations University (FAO/WHO/UNU), Schofield-HW and Harris-Benedict. Agreement between indirect calorimetry and predicted equations was assessed following the Bland-Altman method. Results: In the entire cohort group, predicted REE from all three equations were significantly lower compared to MREE (p < 0.05). There was poor agreement between the MREE and predicted using all three equations. The Schofield-HW equation showed the lowest mean MREE-PREE difference: 635 ± 526 kcal/day (limits of agreement -608 and 1878 kcal/day; 95{\%} confidence interval for the bias 525-745 kcal/day). Additionally, all three equations under predicted REE and were not significantly different from one another (p = 0.98). Conclusions: Until more accurate predicted equations are developed, we recommend indirect calorimetry measurements for determining resting energy expenditure in severely burned children.",
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AB - Introduction: Knowledge of a child's resting energy expenditure (REE) is essential in optimizing nutritional support for severely burned children. The provision of adequate nutritional support is vital in order to avoid the consequences of malnutrition or overfeeding. Nutritional requirements for severely burned children are often based on equations for estimates of REE. The accuracy of the predictive equations of REE has been questioned and many authors have advocated the measurement of REE. This study tests the hypothesis that estimates of REE vary significantly from measured REE (MREE) in a population of severely burned children, and are not accurate for determining nutritional requirements. Methods: In 91 severely burned children aged between 3 and 18 years, REE was measured by indirect calorimetry (MREE) at the height of the hypermetabolic response and compared with predicted equations (PREE) from the Food and Agriculture/World Health Organization/United Nations University (FAO/WHO/UNU), Schofield-HW and Harris-Benedict. Agreement between indirect calorimetry and predicted equations was assessed following the Bland-Altman method. Results: In the entire cohort group, predicted REE from all three equations were significantly lower compared to MREE (p < 0.05). There was poor agreement between the MREE and predicted using all three equations. The Schofield-HW equation showed the lowest mean MREE-PREE difference: 635 ± 526 kcal/day (limits of agreement -608 and 1878 kcal/day; 95% confidence interval for the bias 525-745 kcal/day). Additionally, all three equations under predicted REE and were not significantly different from one another (p = 0.98). Conclusions: Until more accurate predicted equations are developed, we recommend indirect calorimetry measurements for determining resting energy expenditure in severely burned children.

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