Restoration of suppressed immunity in burned mice with cimetidine

Ramon Zapata Sirvent, J. F. Hansbrough, V. Peterson, X. W. Wang, H. Claman

Research output: Contribution to journalArticle

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Abstract

Thermal injury has shown to result in suppression of many aspects of immunity. We studied the effect of cimetidine on suppressed cell mediated immunity in burned mice, utilizing a method of quantitating sensitivity to the contact antigen, 2.4-dinitrofluorobenzene. Daily administration of cimetidine resulted in maintenance of normal cell mediated immunity in these otherwise immuno-suppressed animals. This effect may be secondary to the antagonism of cimetidine with histamine H2 receptors on suppressor cells. Immunorestoration with cimetidine may improve resistance of the burned host to infectious emplications.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalChinese Medical Journal
Volume98
Issue number5
StatePublished - Dec 1 1985
Externally publishedYes

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Cimetidine
Immunity
Cellular Immunity
Dinitrofluorobenzene
Histamine H2 Receptors
Contact Dermatitis
Hot Temperature
Maintenance
Antigens
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zapata Sirvent, R., Hansbrough, J. F., Peterson, V., Wang, X. W., & Claman, H. (1985). Restoration of suppressed immunity in burned mice with cimetidine. Chinese Medical Journal, 98(5), 384-387.

Restoration of suppressed immunity in burned mice with cimetidine. / Zapata Sirvent, Ramon; Hansbrough, J. F.; Peterson, V.; Wang, X. W.; Claman, H.

In: Chinese Medical Journal, Vol. 98, No. 5, 01.12.1985, p. 384-387.

Research output: Contribution to journalArticle

Zapata Sirvent, R, Hansbrough, JF, Peterson, V, Wang, XW & Claman, H 1985, 'Restoration of suppressed immunity in burned mice with cimetidine', Chinese Medical Journal, vol. 98, no. 5, pp. 384-387.
Zapata Sirvent R, Hansbrough JF, Peterson V, Wang XW, Claman H. Restoration of suppressed immunity in burned mice with cimetidine. Chinese Medical Journal. 1985 Dec 1;98(5):384-387.
Zapata Sirvent, Ramon ; Hansbrough, J. F. ; Peterson, V. ; Wang, X. W. ; Claman, H. / Restoration of suppressed immunity in burned mice with cimetidine. In: Chinese Medical Journal. 1985 ; Vol. 98, No. 5. pp. 384-387.
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