Restriction and expansion of Ehrlichia strain diversity

Xue jie Yu; Jere W. McBride; David H. Walker

doi:10.1016/j.vetpar.2006.08.027

Restriction and expansion of Ehrlichia strain diversity

Xue jie Yu, Jere W. McBride, David H. Walker

Pathology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Ehrlichia are tick-borne gram negative, obligately intracellular bacteria. The 16S rRNA gene DNA sequences are highly conserved among strains of each Ehrlichia species. The 28-kDa/Map-1 outer membrane protein genes are highly diversified among strains of Ehrlichia chaffeensis and E. ruminantium, but are highly conserved among E. canis isolates. The diversity of the immunodominant proteins of E. chaffeensis and E. ruminantium in contrast with the conservation of the immunodominant proteins of E. canis suggests that E. chaffeensis and E. ruminantium face more host immune pressure than E. canis or that E. chaffeensis and E. ruminantium evolved earlier than E. canis and have diverged.

Original language	English (US)
Pages (from-to)	337-346
Number of pages	10
Journal	Veterinary Parasitology
Volume	143
Issue number	3-4
DOIs	https://doi.org/10.1016/j.vetpar.2006.08.027
State	Published - Feb 28 2007

Keywords

Ehrlichia
Genetic variation
Outer membrane protein

ASJC Scopus subject areas

Parasitology
General Veterinary

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10.1016/j.vetpar.2006.08.027

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title = "Restriction and expansion of Ehrlichia strain diversity",

abstract = "Ehrlichia are tick-borne gram negative, obligately intracellular bacteria. The 16S rRNA gene DNA sequences are highly conserved among strains of each Ehrlichia species. The 28-kDa/Map-1 outer membrane protein genes are highly diversified among strains of Ehrlichia chaffeensis and E. ruminantium, but are highly conserved among E. canis isolates. The diversity of the immunodominant proteins of E. chaffeensis and E. ruminantium in contrast with the conservation of the immunodominant proteins of E. canis suggests that E. chaffeensis and E. ruminantium face more host immune pressure than E. canis or that E. chaffeensis and E. ruminantium evolved earlier than E. canis and have diverged.",

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AU - Yu, Xue jie

AU - McBride, Jere W.

AU - Walker, David H.

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N2 - Ehrlichia are tick-borne gram negative, obligately intracellular bacteria. The 16S rRNA gene DNA sequences are highly conserved among strains of each Ehrlichia species. The 28-kDa/Map-1 outer membrane protein genes are highly diversified among strains of Ehrlichia chaffeensis and E. ruminantium, but are highly conserved among E. canis isolates. The diversity of the immunodominant proteins of E. chaffeensis and E. ruminantium in contrast with the conservation of the immunodominant proteins of E. canis suggests that E. chaffeensis and E. ruminantium face more host immune pressure than E. canis or that E. chaffeensis and E. ruminantium evolved earlier than E. canis and have diverged.

AB - Ehrlichia are tick-borne gram negative, obligately intracellular bacteria. The 16S rRNA gene DNA sequences are highly conserved among strains of each Ehrlichia species. The 28-kDa/Map-1 outer membrane protein genes are highly diversified among strains of Ehrlichia chaffeensis and E. ruminantium, but are highly conserved among E. canis isolates. The diversity of the immunodominant proteins of E. chaffeensis and E. ruminantium in contrast with the conservation of the immunodominant proteins of E. canis suggests that E. chaffeensis and E. ruminantium face more host immune pressure than E. canis or that E. chaffeensis and E. ruminantium evolved earlier than E. canis and have diverged.

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KW - Genetic variation

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Restriction and expansion of Ehrlichia strain diversity

Abstract

Keywords

ASJC Scopus subject areas

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