Resurgence of west nile neurologic disease in the United States in 2012: What happened? What needs to be done?

David Beasley, Alan Barrett, Robert B. Tesh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The resurgence in cases of neurologic disease caused by West Nile virus (WNV) in the United States in 2012 came as a surprise to the general public and to many non-arbovirus researchers. Following the introduction of WNV into the US in 1999, the number of human infections rose dramatically, peaking in 2002-03. However, cases declined from 2008-11, and it was unclear if the virus would continue to have a low-level endemic transmission pattern with occasional outbreaks, like the related flavivirus, Saint Louis encephalitis virus, or a more active pattern with annual outbreaks, including occasional years with large epidemics, like Japanese encephalitis virus. The large epidemic in 2012 suggests that the United States can expect periodic outbreaks of West Nile fever and neurologic disease in the coming years. In this paper, we consider the causes of the upsurge in WNV infections during the past year and their implications for future research and disease control measures.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalAntiviral Research
Volume99
Issue number1
DOIs
StatePublished - 2013

Fingerprint

West Nile virus
Nervous System Diseases
Disease Outbreaks
Japanese Encephalitis Virus
West Nile Fever
St. Louis Encephalitis Viruses
Flavivirus
Virus Diseases
Research Personnel
Viruses
Infection

Keywords

  • Arbovirus
  • Neuroinvasive disease
  • Viral encephalitis
  • West nile virus

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

Resurgence of west nile neurologic disease in the United States in 2012 : What happened? What needs to be done? / Beasley, David; Barrett, Alan; Tesh, Robert B.

In: Antiviral Research, Vol. 99, No. 1, 2013, p. 1-5.

Research output: Contribution to journalArticle

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