Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution

D. E. Runyon, S. P. Bruttig, M. A. Dubick, C. B. Clifford, George Kramer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prehospital fluid resuscitation of traumatic injury is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near- saturated salt-dextran solution (SSD) administered through a new device, which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady-state baseline was achieved, all animals were hemorrhaged to 45 mm Hg for one hour. Half of the hemorrhaged animals were infused intraosseously with either normal saline (NS) or SSD until cardiac output was restored to the baseline value. No further infusion was given and animals were monitored for 2 hours. Both regimens were able to restore cardiac output to the baseline value, but only 1.3 ± 0.1 mL/kg of SSD was required vs. 31.6 ± 6.3 mL/kg for NS. In addition, cardiac output was better sustained after 2 hours with SSD than with NS. No deleterious effects of IO infusion of SSD were observed. From the improvement in cardiovascular variables and the lack of significant sternal or pulmonary pathologic perturbations, these data suggest that IO infusion of SSD can effectively treat hypovolemia and may allow field treatment when logistic considerations make conventional resuscitation impractical.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalJournal of Trauma
Volume36
Issue number1
StatePublished - 1994

Fingerprint

Intraosseous Infusions
Hypovolemia
Dextrans
Resuscitation
Swine
Salts
Cardiac Output
Blood Vessels
Bone Marrow
Equipment and Supplies
Lung
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution. / Runyon, D. E.; Bruttig, S. P.; Dubick, M. A.; Clifford, C. B.; Kramer, George.

In: Journal of Trauma, Vol. 36, No. 1, 1994, p. 11-19.

Research output: Contribution to journalArticle

Runyon, DE, Bruttig, SP, Dubick, MA, Clifford, CB & Kramer, G 1994, 'Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution', Journal of Trauma, vol. 36, no. 1, pp. 11-19.
Runyon, D. E. ; Bruttig, S. P. ; Dubick, M. A. ; Clifford, C. B. ; Kramer, George. / Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution. In: Journal of Trauma. 1994 ; Vol. 36, No. 1. pp. 11-19.
@article{6c13437dbf9d4fe984287072e9d0198b,
title = "Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution",
abstract = "Prehospital fluid resuscitation of traumatic injury is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near- saturated salt-dextran solution (SSD) administered through a new device, which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady-state baseline was achieved, all animals were hemorrhaged to 45 mm Hg for one hour. Half of the hemorrhaged animals were infused intraosseously with either normal saline (NS) or SSD until cardiac output was restored to the baseline value. No further infusion was given and animals were monitored for 2 hours. Both regimens were able to restore cardiac output to the baseline value, but only 1.3 ± 0.1 mL/kg of SSD was required vs. 31.6 ± 6.3 mL/kg for NS. In addition, cardiac output was better sustained after 2 hours with SSD than with NS. No deleterious effects of IO infusion of SSD were observed. From the improvement in cardiovascular variables and the lack of significant sternal or pulmonary pathologic perturbations, these data suggest that IO infusion of SSD can effectively treat hypovolemia and may allow field treatment when logistic considerations make conventional resuscitation impractical.",
author = "Runyon, {D. E.} and Bruttig, {S. P.} and Dubick, {M. A.} and Clifford, {C. B.} and George Kramer",
year = "1994",
language = "English (US)",
volume = "36",
pages = "11--19",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Resuscitation from hypovolemia in swine with intraosseous infusion of a saturated salt-dextran solution

AU - Runyon, D. E.

AU - Bruttig, S. P.

AU - Dubick, M. A.

AU - Clifford, C. B.

AU - Kramer, George

PY - 1994

Y1 - 1994

N2 - Prehospital fluid resuscitation of traumatic injury is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near- saturated salt-dextran solution (SSD) administered through a new device, which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady-state baseline was achieved, all animals were hemorrhaged to 45 mm Hg for one hour. Half of the hemorrhaged animals were infused intraosseously with either normal saline (NS) or SSD until cardiac output was restored to the baseline value. No further infusion was given and animals were monitored for 2 hours. Both regimens were able to restore cardiac output to the baseline value, but only 1.3 ± 0.1 mL/kg of SSD was required vs. 31.6 ± 6.3 mL/kg for NS. In addition, cardiac output was better sustained after 2 hours with SSD than with NS. No deleterious effects of IO infusion of SSD were observed. From the improvement in cardiovascular variables and the lack of significant sternal or pulmonary pathologic perturbations, these data suggest that IO infusion of SSD can effectively treat hypovolemia and may allow field treatment when logistic considerations make conventional resuscitation impractical.

AB - Prehospital fluid resuscitation of traumatic injury is limited by difficulty in delivering large volumes of fluid in the field and time delays associated with gaining vascular access. We addressed these limitations in 14 anesthetized swine by evaluating a highly efficient volume expander, a near- saturated salt-dextran solution (SSD) administered through a new device, which gains vascular access via intraosseous (IO) infusion into the sternal bone marrow. After a steady-state baseline was achieved, all animals were hemorrhaged to 45 mm Hg for one hour. Half of the hemorrhaged animals were infused intraosseously with either normal saline (NS) or SSD until cardiac output was restored to the baseline value. No further infusion was given and animals were monitored for 2 hours. Both regimens were able to restore cardiac output to the baseline value, but only 1.3 ± 0.1 mL/kg of SSD was required vs. 31.6 ± 6.3 mL/kg for NS. In addition, cardiac output was better sustained after 2 hours with SSD than with NS. No deleterious effects of IO infusion of SSD were observed. From the improvement in cardiovascular variables and the lack of significant sternal or pulmonary pathologic perturbations, these data suggest that IO infusion of SSD can effectively treat hypovolemia and may allow field treatment when logistic considerations make conventional resuscitation impractical.

UR - http://www.scopus.com/inward/record.url?scp=0028079535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028079535&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 11

EP - 19

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 1

ER -