Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran

J. M.S. Pascual, D. E. Runyon, J. C. Watson, C. B. Clifford, M. A. Dubick, G. C. Kramer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A 7.5% sodium chloride/6% Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25% NaCl/24% Dextran solution (SSD), compared to HSD and 0.9% NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 ± 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 ± 1.3 and 1.7 ± 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10% of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalCirculatory Shock
Volume40
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • acute phlebitis
  • cardiac output
  • colloidosmotic pressure
  • fluid balance
  • hemodynamics
  • hemolysis
  • hemorrhagic shock
  • hypertonic solution
  • plasma volume
  • thoracotomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Pascual, J. M. S., Runyon, D. E., Watson, J. C., Clifford, C. B., Dubick, M. A., & Kramer, G. C. (1993). Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran. Circulatory Shock, 40(2), 115-124.