Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin

M. J. Muller, M. A. Hollyoak, Z. Moaveni, Tim La H Brown, David Herndon, J. P. Heggers

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Inhibition of wound contraction by topical anti microbial agents has been described. The purpose of this study was to further investigate that phenomenon and to explore the effect that other agents such as Aloe vera might have on this process. Full-thickness excised wounds were created on the dorsum of Sprague-Dawley rats under anaesthesia. The wounds were treated with topical agents three times daily for fourteen days, then observed until healed. Groups were: saline control, placebo (aqueous cream) control, silver sulphadiazine (SSD) cream 1%, SSD 0.5%, SSD 1% with Aloe vera, SSD 1% with nystatin, nystatin. Wound surface areas were measured each three days. Time to 50% and 90% healing was compared using ANOVA. Wound half-life and healing times were shortest in the SSD/Aloe vera and nystatin groups (P<0.05) and longest in the 1% SSD and saline control groups. The placebo group (aqueous cream) healed in a significantly shorter time (P<0.05) than the control (saline) group. Wound contraction was delayed by saline and SSD. Nystatin and Aloe vera, when added to SSD, reversed that effect. These data suggest that a dry wound (saline) heals slowly. Infection control without delay of wound healing is most appealing and clinical trials are planned.

Original languageEnglish (US)
Pages (from-to)834-836
Number of pages3
JournalBurns
Volume29
Issue number8
DOIs
StatePublished - Dec 2003
Externally publishedYes

Fingerprint

Silver Sulfadiazine
Aloe
Sulfadiazine
Nystatin
Silver
Wound Healing
Wounds and Injuries
Placebos
Control Groups
Infection Control
Anti-Infective Agents
Sprague Dawley Rats
Half-Life
Analysis of Variance
Anesthesia
Clinical Trials

Keywords

  • Aloe vera
  • Antimicrobial
  • Nystatin
  • Silver sulfadiazine
  • Wound healing

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Muller, M. J., Hollyoak, M. A., Moaveni, Z., Brown, T. L. H., Herndon, D., & Heggers, J. P. (2003). Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Burns, 29(8), 834-836. https://doi.org/10.1016/S0305-4179(03)00198-0

Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. / Muller, M. J.; Hollyoak, M. A.; Moaveni, Z.; Brown, Tim La H; Herndon, David; Heggers, J. P.

In: Burns, Vol. 29, No. 8, 12.2003, p. 834-836.

Research output: Contribution to journalArticle

Muller, MJ, Hollyoak, MA, Moaveni, Z, Brown, TLH, Herndon, D & Heggers, JP 2003, 'Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin', Burns, vol. 29, no. 8, pp. 834-836. https://doi.org/10.1016/S0305-4179(03)00198-0
Muller MJ, Hollyoak MA, Moaveni Z, Brown TLH, Herndon D, Heggers JP. Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. Burns. 2003 Dec;29(8):834-836. https://doi.org/10.1016/S0305-4179(03)00198-0
Muller, M. J. ; Hollyoak, M. A. ; Moaveni, Z. ; Brown, Tim La H ; Herndon, David ; Heggers, J. P. / Retardation of wound healing by silver sulfadiazine is reversed by Aloe vera and nystatin. In: Burns. 2003 ; Vol. 29, No. 8. pp. 834-836.
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