Retinal Thickening in Iridocyclitis

Chelsea G. Castellano, Sandra S. Stinnett, Priyatham S. Mettu, Rex M. McCallum, Glenn J. Jaffe

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. Design: Retrospective, observational case series. Methods: Records were reviewed of patients seen at the Duke University Eye Center Uveitis Clinic from January 2002 through March 2008. Patients with unilateral iridocyclitis without panuveitis, vitreitis, pars planitis, posterior uveitis, or a combination thereof who had undergone optical coherence tomography (OCT) of both eyes were included. The AC cell grade and OCT-RT measurements were recorded. Subretinal fluid and intraretinal cysts were determined from OCT scans according to Duke Reading Center guidelines. Results: Forty-three patients were studied. RT typically was present in a ring-like distribution around the fovea. The median difference between the study eye and fellow eye in RT was statistically significant for total macular volume (TMV) and for all OCT subfields (P < .001). In the study eye, there was a modest correlation between the RT and AC cell grade for the OCT-TMV (P = .039; r2 = 0.1) and the subfield comprised of the quadrants in the outer ring on OCT (P = .027; r2 = 0.12), and between RT and visual acuity for OCT-TMV and all but the central subfields (P = .003 to .007; r2 = 0.261 to 0.227). RT decreased after anti-inflammatory therapy. Conclusions: RT is strongly associated with iridocyclitis and decreases after treatment. RT, as determined by OCT, is a useful clinical parameter to evaluate patients with iridocyclitis and to monitor response to treatment.

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Volume148
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Iridocyclitis
Optical Coherence Tomography
Anterior Chamber
Visual Acuity
Pars Planitis
Panuveitis
Posterior Uveitis
Subretinal Fluid
Uveitis
Cysts
Reading
Anti-Inflammatory Agents
Therapeutics
Guidelines
Inflammation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Castellano, C. G., Stinnett, S. S., Mettu, P. S., McCallum, R. M., & Jaffe, G. J. (2009). Retinal Thickening in Iridocyclitis. American Journal of Ophthalmology, 148(3). https://doi.org/10.1016/j.ajo.2009.03.034

Retinal Thickening in Iridocyclitis. / Castellano, Chelsea G.; Stinnett, Sandra S.; Mettu, Priyatham S.; McCallum, Rex M.; Jaffe, Glenn J.

In: American Journal of Ophthalmology, Vol. 148, No. 3, 09.2009.

Research output: Contribution to journalArticle

Castellano, Chelsea G. ; Stinnett, Sandra S. ; Mettu, Priyatham S. ; McCallum, Rex M. ; Jaffe, Glenn J. / Retinal Thickening in Iridocyclitis. In: American Journal of Ophthalmology. 2009 ; Vol. 148, No. 3.
@article{7a1a0fa5216942a2bf9d58ca2bd9605a,
title = "Retinal Thickening in Iridocyclitis",
abstract = "Purpose: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. Design: Retrospective, observational case series. Methods: Records were reviewed of patients seen at the Duke University Eye Center Uveitis Clinic from January 2002 through March 2008. Patients with unilateral iridocyclitis without panuveitis, vitreitis, pars planitis, posterior uveitis, or a combination thereof who had undergone optical coherence tomography (OCT) of both eyes were included. The AC cell grade and OCT-RT measurements were recorded. Subretinal fluid and intraretinal cysts were determined from OCT scans according to Duke Reading Center guidelines. Results: Forty-three patients were studied. RT typically was present in a ring-like distribution around the fovea. The median difference between the study eye and fellow eye in RT was statistically significant for total macular volume (TMV) and for all OCT subfields (P < .001). In the study eye, there was a modest correlation between the RT and AC cell grade for the OCT-TMV (P = .039; r2 = 0.1) and the subfield comprised of the quadrants in the outer ring on OCT (P = .027; r2 = 0.12), and between RT and visual acuity for OCT-TMV and all but the central subfields (P = .003 to .007; r2 = 0.261 to 0.227). RT decreased after anti-inflammatory therapy. Conclusions: RT is strongly associated with iridocyclitis and decreases after treatment. RT, as determined by OCT, is a useful clinical parameter to evaluate patients with iridocyclitis and to monitor response to treatment.",
author = "Castellano, {Chelsea G.} and Stinnett, {Sandra S.} and Mettu, {Priyatham S.} and McCallum, {Rex M.} and Jaffe, {Glenn J.}",
year = "2009",
month = "9",
doi = "10.1016/j.ajo.2009.03.034",
language = "English (US)",
volume = "148",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Retinal Thickening in Iridocyclitis

AU - Castellano, Chelsea G.

AU - Stinnett, Sandra S.

AU - Mettu, Priyatham S.

AU - McCallum, Rex M.

AU - Jaffe, Glenn J.

PY - 2009/9

Y1 - 2009/9

N2 - Purpose: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. Design: Retrospective, observational case series. Methods: Records were reviewed of patients seen at the Duke University Eye Center Uveitis Clinic from January 2002 through March 2008. Patients with unilateral iridocyclitis without panuveitis, vitreitis, pars planitis, posterior uveitis, or a combination thereof who had undergone optical coherence tomography (OCT) of both eyes were included. The AC cell grade and OCT-RT measurements were recorded. Subretinal fluid and intraretinal cysts were determined from OCT scans according to Duke Reading Center guidelines. Results: Forty-three patients were studied. RT typically was present in a ring-like distribution around the fovea. The median difference between the study eye and fellow eye in RT was statistically significant for total macular volume (TMV) and for all OCT subfields (P < .001). In the study eye, there was a modest correlation between the RT and AC cell grade for the OCT-TMV (P = .039; r2 = 0.1) and the subfield comprised of the quadrants in the outer ring on OCT (P = .027; r2 = 0.12), and between RT and visual acuity for OCT-TMV and all but the central subfields (P = .003 to .007; r2 = 0.261 to 0.227). RT decreased after anti-inflammatory therapy. Conclusions: RT is strongly associated with iridocyclitis and decreases after treatment. RT, as determined by OCT, is a useful clinical parameter to evaluate patients with iridocyclitis and to monitor response to treatment.

AB - Purpose: To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. Design: Retrospective, observational case series. Methods: Records were reviewed of patients seen at the Duke University Eye Center Uveitis Clinic from January 2002 through March 2008. Patients with unilateral iridocyclitis without panuveitis, vitreitis, pars planitis, posterior uveitis, or a combination thereof who had undergone optical coherence tomography (OCT) of both eyes were included. The AC cell grade and OCT-RT measurements were recorded. Subretinal fluid and intraretinal cysts were determined from OCT scans according to Duke Reading Center guidelines. Results: Forty-three patients were studied. RT typically was present in a ring-like distribution around the fovea. The median difference between the study eye and fellow eye in RT was statistically significant for total macular volume (TMV) and for all OCT subfields (P < .001). In the study eye, there was a modest correlation between the RT and AC cell grade for the OCT-TMV (P = .039; r2 = 0.1) and the subfield comprised of the quadrants in the outer ring on OCT (P = .027; r2 = 0.12), and between RT and visual acuity for OCT-TMV and all but the central subfields (P = .003 to .007; r2 = 0.261 to 0.227). RT decreased after anti-inflammatory therapy. Conclusions: RT is strongly associated with iridocyclitis and decreases after treatment. RT, as determined by OCT, is a useful clinical parameter to evaluate patients with iridocyclitis and to monitor response to treatment.

UR - http://www.scopus.com/inward/record.url?scp=68949103405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949103405&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2009.03.034

DO - 10.1016/j.ajo.2009.03.034

M3 - Article

C2 - 19477710

AN - SCOPUS:68949103405

VL - 148

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 3

ER -