Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity

Shijin Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, Hongzhen Hu

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically, retinoids are effective in treating many skin disorders and cancers. Application of retinoids evokes substantial irritating side effects, including pain and inflammation; however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. Here we show that both naturally occurring and synthetic retinoids activate recombinant or native transient receptor potential channel vanilloid subtype 1 (TRPV1), an irritant receptor for capsaicin, the pungent ingredient of chili peppers. In vivo, retinoids produced pain-related behaviors that were either eliminated or significantly reduced by genetic or pharmacological inhibition of TRPV1 function. These findings identify TRPV1 as an ionotropic receptor for retinoids and provide cellular and molecular insights into retinoid-evoked hypersensitivity. These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity.

    Original languageEnglish (US)
    Pages (from-to)3941-3951
    Number of pages11
    JournalJournal of Clinical Investigation
    Volume123
    Issue number9
    DOIs
    StatePublished - Sep 3 2013

    Fingerprint

    Transient Receptor Potential Channels
    Irritants
    Retinoids
    Hypersensitivity
    Pain
    Capsicum
    Capsaicin
    Skin Neoplasms
    Vitamin A
    Cell Differentiation
    Cell Proliferation
    Pharmacology
    Inflammation

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. / Yin, Shijin; Luo, Jialie; Qian, Aihua; Du, Junhui; Yang, Qing; Zhou, Shentai; Yu, Weihua; Du, Guangwei; Clark, Richard B.; Walters, Edgar T.; Carlton, Susan M.; Hu, Hongzhen.

    In: Journal of Clinical Investigation, Vol. 123, No. 9, 03.09.2013, p. 3941-3951.

    Research output: Contribution to journalArticle

    Yin, S, Luo, J, Qian, A, Du, J, Yang, Q, Zhou, S, Yu, W, Du, G, Clark, RB, Walters, ET, Carlton, SM & Hu, H 2013, 'Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity', Journal of Clinical Investigation, vol. 123, no. 9, pp. 3941-3951. https://doi.org/10.1172/JCI66413
    Yin, Shijin ; Luo, Jialie ; Qian, Aihua ; Du, Junhui ; Yang, Qing ; Zhou, Shentai ; Yu, Weihua ; Du, Guangwei ; Clark, Richard B. ; Walters, Edgar T. ; Carlton, Susan M. ; Hu, Hongzhen. / Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. In: Journal of Clinical Investigation. 2013 ; Vol. 123, No. 9. pp. 3941-3951.
    @article{915e109ace6b4ab581a32fed564d81af,
    title = "Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity",
    abstract = "Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically, retinoids are effective in treating many skin disorders and cancers. Application of retinoids evokes substantial irritating side effects, including pain and inflammation; however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. Here we show that both naturally occurring and synthetic retinoids activate recombinant or native transient receptor potential channel vanilloid subtype 1 (TRPV1), an irritant receptor for capsaicin, the pungent ingredient of chili peppers. In vivo, retinoids produced pain-related behaviors that were either eliminated or significantly reduced by genetic or pharmacological inhibition of TRPV1 function. These findings identify TRPV1 as an ionotropic receptor for retinoids and provide cellular and molecular insights into retinoid-evoked hypersensitivity. These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity.",
    author = "Shijin Yin and Jialie Luo and Aihua Qian and Junhui Du and Qing Yang and Shentai Zhou and Weihua Yu and Guangwei Du and Clark, {Richard B.} and Walters, {Edgar T.} and Carlton, {Susan M.} and Hongzhen Hu",
    year = "2013",
    month = "9",
    day = "3",
    doi = "10.1172/JCI66413",
    language = "English (US)",
    volume = "123",
    pages = "3941--3951",
    journal = "Journal of Clinical Investigation",
    issn = "0021-9738",
    publisher = "The American Society for Clinical Investigation",
    number = "9",

    }

    TY - JOUR

    T1 - Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity

    AU - Yin, Shijin

    AU - Luo, Jialie

    AU - Qian, Aihua

    AU - Du, Junhui

    AU - Yang, Qing

    AU - Zhou, Shentai

    AU - Yu, Weihua

    AU - Du, Guangwei

    AU - Clark, Richard B.

    AU - Walters, Edgar T.

    AU - Carlton, Susan M.

    AU - Hu, Hongzhen

    PY - 2013/9/3

    Y1 - 2013/9/3

    N2 - Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically, retinoids are effective in treating many skin disorders and cancers. Application of retinoids evokes substantial irritating side effects, including pain and inflammation; however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. Here we show that both naturally occurring and synthetic retinoids activate recombinant or native transient receptor potential channel vanilloid subtype 1 (TRPV1), an irritant receptor for capsaicin, the pungent ingredient of chili peppers. In vivo, retinoids produced pain-related behaviors that were either eliminated or significantly reduced by genetic or pharmacological inhibition of TRPV1 function. These findings identify TRPV1 as an ionotropic receptor for retinoids and provide cellular and molecular insights into retinoid-evoked hypersensitivity. These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity.

    AB - Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically, retinoids are effective in treating many skin disorders and cancers. Application of retinoids evokes substantial irritating side effects, including pain and inflammation; however, the precise mechanisms accounting for the sensory hypersensitivity are not understood. Here we show that both naturally occurring and synthetic retinoids activate recombinant or native transient receptor potential channel vanilloid subtype 1 (TRPV1), an irritant receptor for capsaicin, the pungent ingredient of chili peppers. In vivo, retinoids produced pain-related behaviors that were either eliminated or significantly reduced by genetic or pharmacological inhibition of TRPV1 function. These findings identify TRPV1 as an ionotropic receptor for retinoids and provide cellular and molecular insights into retinoid-evoked hypersensitivity. These findings also suggest that selective TRPV1 antagonists are potential therapeutic drugs for treating retinoid-induced sensory hypersensitivity.

    UR - http://www.scopus.com/inward/record.url?scp=84883506574&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84883506574&partnerID=8YFLogxK

    U2 - 10.1172/JCI66413

    DO - 10.1172/JCI66413

    M3 - Article

    VL - 123

    SP - 3941

    EP - 3951

    JO - Journal of Clinical Investigation

    JF - Journal of Clinical Investigation

    SN - 0021-9738

    IS - 9

    ER -