Reversible right ventricular dysfunction in patients with HIV infection

Umamahesh Rangasetty, Atiar M. Rahman, Nasir Hussain

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Human immunodeficiency virus-related cardiomyopathy is characterized by global left ventricular (LV) dysfunction commonly associated with biventricular dilation. Human immunodeficiency virus (HIV) cardiomyopathy carries a poor prognosis, and the role of antiretroviral therapy in the reversal of heart failure is not very clear. We report two patients with HIV infection who presented with severe right ventricular (RV) dysfunction in the absence of pulmonary parenchymal, pulmonary arterial and left ventricular myocardial involvement. During the period of intensive antiretroviral therapy, the symptoms of right heart failure progressively and remarkably improved. This was accompanied by normalization of right ventricular size and RV function documented by repeat echocardiograms. Given that the serologic tests for opportunistic infections were negative, and the RV function improvement correlated with a decrement in the viral load, it is likely that the cardiomyopathy was due to direct infection by HIV. These cases illustrate that there can be isolated involvement of the right heart in the absence of lung, significant pulmonary vascular and left ventricular disease, and also that the antiretroviral therapy might reverse the cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalSouthern Medical Journal
Volume99
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Right Ventricular Dysfunction
Virus Diseases
Cardiomyopathies
HIV
Right Ventricular Function
Lung
Heart Failure
Opportunistic Infections
Left Ventricular Dysfunction
Serologic Tests
Viral Load
Blood Vessels
Dilatation
Therapeutics
Infection

Keywords

  • Antiretroviral therapy
  • Cardiomyopathy
  • HIV
  • Right ventricle

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reversible right ventricular dysfunction in patients with HIV infection. / Rangasetty, Umamahesh; Rahman, Atiar M.; Hussain, Nasir.

In: Southern Medical Journal, Vol. 99, No. 3, 03.2006, p. 274-278.

Research output: Contribution to journalArticle

Rangasetty, Umamahesh ; Rahman, Atiar M. ; Hussain, Nasir. / Reversible right ventricular dysfunction in patients with HIV infection. In: Southern Medical Journal. 2006 ; Vol. 99, No. 3. pp. 274-278.
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