Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

Xiangguo Qiu; Gary Wong; Jonathan Audet; Alexander Bello; Lisa Fernando; Judie B. Alimonti; Hugues Fausther-Bovendo; Haiyan Wei; Jenna Aviles; Ernie Hiatt; Ashley Johnson; Josh Morton; Kelsi Swope; Ognian Bohorov; Natasha Bohorova; Charles Goodman; Do Kim; Michael H. Pauly; Jesus Velasco; James Pettitt; Gene G. Olinger; Kevin Whaley; Bianli Xu; James E. Strong; Larry Zeitlin; Gary P. Kobinger

doi:10.1038/nature13777

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

Xiangguo Qiu, Gary Wong, Jonathan Audet, Alexander Bello, Lisa Fernando, Judie B. Alimonti, Hugues Fausther-Bovendo, Haiyan Wei, Jenna Aviles, Ernie Hiatt, Ashley Johnson, Josh Morton, Kelsi Swope, Ognian Bohorov, Natasha Bohorova, Charles Goodman, Do Kim, Michael H. Pauly, Jesus Velasco, James PettittGene G. Olinger, Kevin Whaley, Bianli Xu, James E. Strong, Larry Zeitlin, Gary P. Kobinger

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847 Scopus citations

Abstract

Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use.

Original language	English (US)
Pages (from-to)	47-53
Number of pages	7
Journal	Nature
Volume	514
Issue number	7520
DOIs	https://doi.org/10.1038/nature13777
State	Published - Oct 2 2014
Externally published	Yes

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Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J. B., Fausther-Bovendo, H., Wei, H., Aviles, J., Hiatt, E., Johnson, A., Morton, J., Swope, K., Bohorov, O., Bohorova, N., Goodman, C., Kim, D., Pauly, M. H., Velasco, J., ... Kobinger, G. P. (2014). Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature, 514(7520), 47-53. https://doi.org/10.1038/nature13777

Qiu, X, Wong, G, Audet, J, Bello, A, Fernando, L, Alimonti, JB, Fausther-Bovendo, H, Wei, H, Aviles, J, Hiatt, E, Johnson, A, Morton, J, Swope, K, Bohorov, O, Bohorova, N, Goodman, C, Kim, D, Pauly, MH, Velasco, J, Pettitt, J, Olinger, GG, Whaley, K, Xu, B, Strong, JE, Zeitlin, L & Kobinger, GP 2014, 'Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp', Nature, vol. 514, no. 7520, pp. 47-53. https://doi.org/10.1038/nature13777

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abstract = "Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge. High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use.",

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Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

Abstract

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