Revolution in lung cancer new challenges for the surgical pathologist

Philip T. Cagle, Timothy C. Allen, Sanja Dacie, Mary Beth Beasley, Alain C. Borczuk, Lucian R. Chirieac, Rodolfo Laucirica, Jae Y. Ro, Keith M. Kerr

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Context.-Traditionally, lung cancer has been viewed as an aggressive, relentlessly progressive disease with few treatment options and poor survival. The traditional role of the pathologist has been primarily to differentiate small cell carcinoma from non-small cell carcinoma on biopsy and cytology specimens and to stage non-small cell carcinomas that underwent resection. In recent years, our concepts of lung cancer have undergone a revolution, including (1) the advent of successful, new, moleculartargeted therapies for lung cancer, many of which are associated with specific histologic cell types and subtypes; (2) new observations on the natural history of lung cancer derived from ongoing high-resolution computed tomography screening studies and recent histologic findings; and (3) proposals to revise the classification of lung cancers, particularly adenocarcinomas, in part because of the first 2 developments. Objective.-To summarize the important, new developments in lung cancer, emphasizing the role of the surgical pathologist in personalized care for patients with lung cancer. Data Sources.-Information about the new developments in lung cancer was obtained from the peer-review medical literature and the authors' experiences. Conclusions.-For decades, we have perceived lung cancer as a relentlessly aggressive and mostly incurable disease for which the surgical pathologist had a limited role. Today, surgical pathologists have an important and expanding role in the diagnosis and treatment of lung cancer, and it is essential to keep informed of new advances.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Volume135
Issue number1
StatePublished - Jan 2011
Externally publishedYes

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Lung Neoplasms
Pathologists
Carcinoma
Peer Review
Small Cell Carcinoma
Information Storage and Retrieval
Cell Biology
Patient Care
Adenocarcinoma
Therapeutics
Tomography
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Cagle, P. T., Allen, T. C., Dacie, S., Beth Beasley, M., Borczuk, A. C., Chirieac, L. R., ... Kerr, K. M. (2011). Revolution in lung cancer new challenges for the surgical pathologist. Archives of Pathology and Laboratory Medicine, 135(1), 110-116.

Revolution in lung cancer new challenges for the surgical pathologist. / Cagle, Philip T.; Allen, Timothy C.; Dacie, Sanja; Beth Beasley, Mary; Borczuk, Alain C.; Chirieac, Lucian R.; Laucirica, Rodolfo; Ro, Jae Y.; Kerr, Keith M.

In: Archives of Pathology and Laboratory Medicine, Vol. 135, No. 1, 01.2011, p. 110-116.

Research output: Contribution to journalArticle

Cagle, PT, Allen, TC, Dacie, S, Beth Beasley, M, Borczuk, AC, Chirieac, LR, Laucirica, R, Ro, JY & Kerr, KM 2011, 'Revolution in lung cancer new challenges for the surgical pathologist', Archives of Pathology and Laboratory Medicine, vol. 135, no. 1, pp. 110-116.
Cagle PT, Allen TC, Dacie S, Beth Beasley M, Borczuk AC, Chirieac LR et al. Revolution in lung cancer new challenges for the surgical pathologist. Archives of Pathology and Laboratory Medicine. 2011 Jan;135(1):110-116.
Cagle, Philip T. ; Allen, Timothy C. ; Dacie, Sanja ; Beth Beasley, Mary ; Borczuk, Alain C. ; Chirieac, Lucian R. ; Laucirica, Rodolfo ; Ro, Jae Y. ; Kerr, Keith M. / Revolution in lung cancer new challenges for the surgical pathologist. In: Archives of Pathology and Laboratory Medicine. 2011 ; Vol. 135, No. 1. pp. 110-116.
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