TY - JOUR
T1 - Revolutionizing prostate cancer treatment
T2 - Prostate Specific Membrane Antigen (PSMA) targeted therapy in modern therapeutics
AU - Ricaurte Fajardo, A.
AU - Marulanda Corzo, V.
AU - Ruder, S.
AU - Cardoza-Ochoa, D. R.
AU - Granados, C. E.
AU - Yadav, D.
AU - Lopez, D.
AU - Fatima, M.
AU - Dutruel, S.
AU - O'Dwyer, E.
AU - Osborne, J. R.
AU - Tagawa, S. T.
AU - Huicochea Castellanos, S.
N1 - Publisher Copyright:
© 2025 Sociedad Española de Medicina Nuclear e Imagen Molecular
PY - 2025/9/1
Y1 - 2025/9/1
N2 - Prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy has reshaped the treatment landscape for metastatic castration-resistant prostate cancer (mCRPC), offering new therapeutic possibilities beyond conventional approaches. Among the most promising strategies is lutetium-177 PSMA-617, which has shown significant benefits in overall survival and durable PSA responses, as demonstrated in several clinical trials. At the same time, the development of novel radionuclides such as actinium-225 has opened the door to more potent treatments capable of overcoming prior resistance, particularly in patients previously exposed to beta emitters. The use of PSMA PET imaging and the identification of predictive biomarkers have helped refine patient selection, contributing to a more personalized approach. Comparative studies with agents like cabazitaxel have further supported the safety and effectiveness of this strategy. This article provides a critical overview of clinical advances in PSMA-targeted radionuclide therapy, examines emerging combination treatments, reviews the development of alpha-emitting agents, and highlights the role of personalized dosimetry in clinical practice, underlining the growing importance of this therapeutic modality across different stages of prostate cancer.
AB - Prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy has reshaped the treatment landscape for metastatic castration-resistant prostate cancer (mCRPC), offering new therapeutic possibilities beyond conventional approaches. Among the most promising strategies is lutetium-177 PSMA-617, which has shown significant benefits in overall survival and durable PSA responses, as demonstrated in several clinical trials. At the same time, the development of novel radionuclides such as actinium-225 has opened the door to more potent treatments capable of overcoming prior resistance, particularly in patients previously exposed to beta emitters. The use of PSMA PET imaging and the identification of predictive biomarkers have helped refine patient selection, contributing to a more personalized approach. Comparative studies with agents like cabazitaxel have further supported the safety and effectiveness of this strategy. This article provides a critical overview of clinical advances in PSMA-targeted radionuclide therapy, examines emerging combination treatments, reviews the development of alpha-emitting agents, and highlights the role of personalized dosimetry in clinical practice, underlining the growing importance of this therapeutic modality across different stages of prostate cancer.
KW - Advanced prostate cancer
KW - Lu-PSMA-617
KW - PET
KW - PSMA
KW - Radionuclides
KW - Targeted therapy
UR - https://www.scopus.com/pages/publications/105004901705
UR - https://www.scopus.com/pages/publications/105004901705#tab=citedBy
U2 - 10.1016/j.remn.2025.500162
DO - 10.1016/j.remn.2025.500162
M3 - Article
AN - SCOPUS:105004901705
SN - 2253-654X
VL - 44
JO - Revista Espanola de Medicina Nuclear e Imagen Molecular
JF - Revista Espanola de Medicina Nuclear e Imagen Molecular
IS - 5
M1 - 500162
ER -