Reye's syndrome: The effect of patient serum on mitochondrial respiration in vitro

Gregory K. Asimakis; June R. Aprille

doi:10.1016/0006-291X(77)91122-6

Reye's syndrome: The effect of patient serum on mitochondrial respiration in vitro

Gregory K. Asimakis, June R. Aprille

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Serum from patients with Reye's Syndrome stimulated state 4 respiration in isolated rat liver mitochondria. Inhibitors of specific mitochondrial functions were tested as potential antagonists of the stimulatory effect of RS serum. Oligomycin, ruthenium red, rotenone and antimycin A were all ineffective in preventing the increase in state 4 respiration, but KCN completely abolished all respiratory activity in the presence of RS serum. We conclude that the putative serum factor stimulates respiration by directly or indirectly interacting with the electron transport chain at a point beyond site II.

Original language	English (US)
Pages (from-to)	1122-1129
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	79
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(77)91122-6
State	Published - Dec 21 1977
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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