Abstract
Serum from patients with Reye's Syndrome stimulated state 4 respiration in isolated rat liver mitochondria. Inhibitors of specific mitochondrial functions were tested as potential antagonists of the stimulatory effect of RS serum. Oligomycin, ruthenium red, rotenone and antimycin A were all ineffective in preventing the increase in state 4 respiration, but KCN completely abolished all respiratory activity in the presence of RS serum. We conclude that the putative serum factor stimulates respiration by directly or indirectly interacting with the electron transport chain at a point beyond site II.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1122-1129 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 79 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 21 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Reye's syndrome : The effect of patient serum on mitochondrial respiration in vitro. / Asimakis, Gregory K.; Aprille, June R.
In: Biochemical and Biophysical Research Communications, Vol. 79, No. 4, 21.12.1977, p. 1122-1129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reye's syndrome
T2 - The effect of patient serum on mitochondrial respiration in vitro
AU - Asimakis, Gregory K.
AU - Aprille, June R.
PY - 1977/12/21
Y1 - 1977/12/21
N2 - Serum from patients with Reye's Syndrome stimulated state 4 respiration in isolated rat liver mitochondria. Inhibitors of specific mitochondrial functions were tested as potential antagonists of the stimulatory effect of RS serum. Oligomycin, ruthenium red, rotenone and antimycin A were all ineffective in preventing the increase in state 4 respiration, but KCN completely abolished all respiratory activity in the presence of RS serum. We conclude that the putative serum factor stimulates respiration by directly or indirectly interacting with the electron transport chain at a point beyond site II.
AB - Serum from patients with Reye's Syndrome stimulated state 4 respiration in isolated rat liver mitochondria. Inhibitors of specific mitochondrial functions were tested as potential antagonists of the stimulatory effect of RS serum. Oligomycin, ruthenium red, rotenone and antimycin A were all ineffective in preventing the increase in state 4 respiration, but KCN completely abolished all respiratory activity in the presence of RS serum. We conclude that the putative serum factor stimulates respiration by directly or indirectly interacting with the electron transport chain at a point beyond site II.
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U2 - 10.1016/0006-291X(77)91122-6
DO - 10.1016/0006-291X(77)91122-6
M3 - Article
VL - 79
SP - 1122
EP - 1129
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -