Rheumatologic and skeletal changes in acromegaly

Steven Lieberman, A. G. Bjorkengren, A. R. Hoffman

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The anabolic functions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in cartilage and bone metabolism are important in the normal physiology of these tissues. The effects of chronic elevation of GH and IGF-I levels on bony structures produce the typical physical changes associated with acromegaly, whereas the effects on cartilage result in arthropathy, which is usually degenerative. This article presents an overview of the physiologic roles of GH and IGF-I in cartilage and bone metabolism, the clinical features of the degenerative arthropathy and other rheumatologic syndromes associated with acromegaly, effects of acromegaly on bone and mineral metabolism, and an unusual bone disease that is occasionally associated with acromegaly, the McCune-Albright syndrome.

Original languageEnglish (US)
Pages (from-to)615-631
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Volume21
Issue number3
StatePublished - 1992
Externally publishedYes

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Acromegaly
Bone
Cartilage
Insulin-Like Growth Factor I
Metabolism
Growth Hormone
Joint Diseases
Bone and Bones
Polyostotic Fibrous Dysplasia
Bone Diseases
Physiology
Minerals
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Lieberman, S., Bjorkengren, A. G., & Hoffman, A. R. (1992). Rheumatologic and skeletal changes in acromegaly. Endocrinology and Metabolism Clinics of North America, 21(3), 615-631.

Rheumatologic and skeletal changes in acromegaly. / Lieberman, Steven; Bjorkengren, A. G.; Hoffman, A. R.

In: Endocrinology and Metabolism Clinics of North America, Vol. 21, No. 3, 1992, p. 615-631.

Research output: Contribution to journalArticle

Lieberman, S, Bjorkengren, AG & Hoffman, AR 1992, 'Rheumatologic and skeletal changes in acromegaly', Endocrinology and Metabolism Clinics of North America, vol. 21, no. 3, pp. 615-631.
Lieberman, Steven ; Bjorkengren, A. G. ; Hoffman, A. R. / Rheumatologic and skeletal changes in acromegaly. In: Endocrinology and Metabolism Clinics of North America. 1992 ; Vol. 21, No. 3. pp. 615-631.
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