Rhinovirus and Asthma Exacerbations

Joshua L. Kennedy, S. Pham, L. Borish

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Rhinovirus (RV) is ubiquitous and typically causes only minor upper respiratory symptoms. However, especially in children and adolescent asthmatics, RV is responsible for most exacerbations. This ability of RV to drive exacerbations typically requires the concomitant presence of exposure to a bystander allergen. Susceptibility to RV-mediated exacerbations is also related to the genetic background of the host, which contributes to greater infectivity, more severe infections, altered immune responses, and to greater inflammation and loss of asthma control. Given these responses, there are several treatments available or being developed that should improve the control of exacerbations related to RV infection.

Original languageEnglish (US)
Pages (from-to)335-344
Number of pages10
JournalImmunology and Allergy Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - Aug 2019
Externally publishedYes

Keywords

  • Allergy
  • Asthma
  • Genetics
  • IgE
  • Rhinovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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