Rhodium(iii)-catalyzed [5+1] annulation of 2-alkenylphenols with maleimides: Access to highly functionalized spirocyclic skeletons

Anil Kumar, Kandikere Ramaiah Prabhu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A new edition of [5+1] annulation reaction of maleimides with 2-alkenylphenols has been discovered under a Rh(iii)-catalytic system. The process leads to an efficient synthesis of valued spirocyclic scaffolds bearing an oxygen-containing spiro carbon in a single step and shows a broad substrate scope with good functional group tolerance. The synthetic utility has been exemplified by synthesizing highly functionalized 2,2-disubstituted-2H-chromene skeletons and a gram-scale synthesis with a low catalyst loading.

Original languageEnglish (US)
Pages (from-to)8194-8197
Number of pages4
JournalChemical Communications
Volume57
Issue number66
DOIs
StatePublished - Aug 25 2021
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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