Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds

Anil Kumar, Kandikere Ramaiah Prabhu

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A Rh(III)-catalyzed cascade C-H activation; regioselective [4 + 2] oxidative annulation; and lactonization of aromatic acids, anhydrides, and acrylic acid derivatives with 4-hydroxy-2-Alkynoates have been disclosed. This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functional group tolerance and excellent site selectivity. Besides, in one step, an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin framework has been synthesized.

Original languageEnglish (US)
Pages (from-to)3548-3559
Number of pages12
JournalJournal of Organic Chemistry
Volume85
Issue number5
DOIs
StatePublished - Mar 6 2020
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Rhodium(III)-Catalyzed C-H Activation: A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds'. Together they form a unique fingerprint.

Cite this