TY - JOUR
T1 - Rhodium(III)-Catalyzed C-H Activation
T2 - A Cascade Approach for the Regioselective Synthesis of Fused Heterocyclic Lactone Scaffolds
AU - Kumar, Anil
AU - Prabhu, Kandikere Ramaiah
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/3/6
Y1 - 2020/3/6
N2 - A Rh(III)-catalyzed cascade C-H activation; regioselective [4 + 2] oxidative annulation; and lactonization of aromatic acids, anhydrides, and acrylic acid derivatives with 4-hydroxy-2-Alkynoates have been disclosed. This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functional group tolerance and excellent site selectivity. Besides, in one step, an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin framework has been synthesized.
AB - A Rh(III)-catalyzed cascade C-H activation; regioselective [4 + 2] oxidative annulation; and lactonization of aromatic acids, anhydrides, and acrylic acid derivatives with 4-hydroxy-2-Alkynoates have been disclosed. This strategy leads to fused heterocyclic lactone scaffolds in a single step with moderate functional group tolerance and excellent site selectivity. Besides, in one step, an antipode of the cephalosol intermediate natural product that contains a tricyclic isocoumarin framework has been synthesized.
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U2 - 10.1021/acs.joc.9b03266
DO - 10.1021/acs.joc.9b03266
M3 - Article
C2 - 31994394
AN - SCOPUS:85081732092
SN - 0022-3263
VL - 85
SP - 3548
EP - 3559
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 5
ER -