Ribonucleases and bacterial virulence

Abidat Lawal, Olufisayo Jejelowo, Ashok Chopra, Jason A. Rosenzweig

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bacterial stress responses provide them the opportunity to survive hostile environments, proliferate and potentially cause diseases in humans and animals. The way in which pathogenic bacteria interact with host immune cells triggers a complicated series of events that include rapid genetic re-programming in response to the various host conditions encountered. Viewed in this light, the bacterial host-cell induced stress response (HCISR) is similar to any other well-characterized environmental stress to which bacteria must respond by upregulating a group of specific stress-responsive genes. Post stress, bacteria must resume their pre-stress genetic program, and, as a consequence, must degrade unnecessary stress responsive transcripts through RNA decay mechanisms. Further, there is a well-established role for several ribonucleases in the cold shock response whereby they modulate the changing transcript landscape in response to the stress, and during acclimation and subsequent genetic re-programming post stress. Recently, ribonucleases have been implicated as virulence-associated factors in several notable Gram-negative pathogens including, the yersiniae, the salmonellae, Helicobacter pylori, Shigella flexneri and Aeromonas hydrophila. This review will focus on the roles played by ribonucleases in bacterial virulence, other bacterial stress responses, and on their novel therapeutic applications.

Original languageEnglish (US)
Pages (from-to)558-571
Number of pages14
JournalMicrobial Biotechnology
Volume4
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

Ribonucleases
Virulence
Bacteria
Cold-Shock Response
Aeromonas hydrophila
Shigella flexneri
Yersinia
Acclimatization
RNA Stability
Virulence Factors
Helicobacter pylori
Salmonella
Pathogens
RNA
Genes
Animals
Therapeutics

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology
  • Biochemistry
  • Bioengineering

Cite this

Ribonucleases and bacterial virulence. / Lawal, Abidat; Jejelowo, Olufisayo; Chopra, Ashok; Rosenzweig, Jason A.

In: Microbial Biotechnology, Vol. 4, No. 5, 09.2011, p. 558-571.

Research output: Contribution to journalArticle

Lawal, Abidat ; Jejelowo, Olufisayo ; Chopra, Ashok ; Rosenzweig, Jason A. / Ribonucleases and bacterial virulence. In: Microbial Biotechnology. 2011 ; Vol. 4, No. 5. pp. 558-571.
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