Rickettsia parkeri: A newly recognized cause of spotted fever rickettsiosis in the United States

Christopher D. Paddock, John W. Sumner, James A. Comer, Sherif R. Zaki, Cynthia S. Goldsmith, Jerome Goddard, Susan McLellan, Cynthia L. Tamminga, Christopher A. Ohl

Research output: Contribution to journalArticle

298 Citations (Scopus)

Abstract

Ticks, including many that bite humans, are hosts to several obligate intracellular bacteria in the spotted fever group (SFG) of the genus Rickettsia. Only Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, has been definitively associated with disease in humans in the United States. Herein we describe disease in a human caused by Rickettsia parkeri, an SFG rickettsia first identified >60 years ago in Gulf Coast ticks (Amblyomma maculatum) collected from the southern United States. Confirmation of the infection was accomplished using serological testing, immunohistochemical staining, cell culture isolation, and molecular methods. Application of specific laboratory assays to clinical specimens obtained from patients with febrile, eschar-associated illnesses following a tick bite may identify additional cases of R. parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States.

Original languageEnglish (US)
Pages (from-to)805-811
Number of pages7
JournalClinical Infectious Diseases
Volume38
Issue number6
DOIs
StatePublished - Mar 15 2004
Externally publishedYes

Fingerprint

Rickettsia
Fever
Ticks
Rickettsia rickettsii
Human Bites
Rocky Mountain Spotted Fever
Tick Bites
Cell Separation
Cell Culture Techniques
Staining and Labeling
Bacteria
Infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Paddock, C. D., Sumner, J. W., Comer, J. A., Zaki, S. R., Goldsmith, C. S., Goddard, J., ... Ohl, C. A. (2004). Rickettsia parkeri: A newly recognized cause of spotted fever rickettsiosis in the United States. Clinical Infectious Diseases, 38(6), 805-811. https://doi.org/10.1086/381894

Rickettsia parkeri : A newly recognized cause of spotted fever rickettsiosis in the United States. / Paddock, Christopher D.; Sumner, John W.; Comer, James A.; Zaki, Sherif R.; Goldsmith, Cynthia S.; Goddard, Jerome; McLellan, Susan; Tamminga, Cynthia L.; Ohl, Christopher A.

In: Clinical Infectious Diseases, Vol. 38, No. 6, 15.03.2004, p. 805-811.

Research output: Contribution to journalArticle

Paddock, CD, Sumner, JW, Comer, JA, Zaki, SR, Goldsmith, CS, Goddard, J, McLellan, S, Tamminga, CL & Ohl, CA 2004, 'Rickettsia parkeri: A newly recognized cause of spotted fever rickettsiosis in the United States', Clinical Infectious Diseases, vol. 38, no. 6, pp. 805-811. https://doi.org/10.1086/381894
Paddock CD, Sumner JW, Comer JA, Zaki SR, Goldsmith CS, Goddard J et al. Rickettsia parkeri: A newly recognized cause of spotted fever rickettsiosis in the United States. Clinical Infectious Diseases. 2004 Mar 15;38(6):805-811. https://doi.org/10.1086/381894
Paddock, Christopher D. ; Sumner, John W. ; Comer, James A. ; Zaki, Sherif R. ; Goldsmith, Cynthia S. ; Goddard, Jerome ; McLellan, Susan ; Tamminga, Cynthia L. ; Ohl, Christopher A. / Rickettsia parkeri : A newly recognized cause of spotted fever rickettsiosis in the United States. In: Clinical Infectious Diseases. 2004 ; Vol. 38, No. 6. pp. 805-811.
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