TY - JOUR
T1 - Rickettsia parkeri
T2 - A newly recognized cause of spotted fever rickettsiosis in the United States
AU - Paddock, Christopher D.
AU - Sumner, John W.
AU - Comer, James A.
AU - Zaki, Sherif R.
AU - Goldsmith, Cynthia S.
AU - Goddard, Jerome
AU - McLellan, Susan L.F.
AU - Tamminga, Cynthia L.
AU - Ohl, Christopher A.
PY - 2004/3/15
Y1 - 2004/3/15
N2 - Ticks, including many that bite humans, are hosts to several obligate intracellular bacteria in the spotted fever group (SFG) of the genus Rickettsia. Only Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, has been definitively associated with disease in humans in the United States. Herein we describe disease in a human caused by Rickettsia parkeri, an SFG rickettsia first identified >60 years ago in Gulf Coast ticks (Amblyomma maculatum) collected from the southern United States. Confirmation of the infection was accomplished using serological testing, immunohistochemical staining, cell culture isolation, and molecular methods. Application of specific laboratory assays to clinical specimens obtained from patients with febrile, eschar-associated illnesses following a tick bite may identify additional cases of R. parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States.
AB - Ticks, including many that bite humans, are hosts to several obligate intracellular bacteria in the spotted fever group (SFG) of the genus Rickettsia. Only Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, has been definitively associated with disease in humans in the United States. Herein we describe disease in a human caused by Rickettsia parkeri, an SFG rickettsia first identified >60 years ago in Gulf Coast ticks (Amblyomma maculatum) collected from the southern United States. Confirmation of the infection was accomplished using serological testing, immunohistochemical staining, cell culture isolation, and molecular methods. Application of specific laboratory assays to clinical specimens obtained from patients with febrile, eschar-associated illnesses following a tick bite may identify additional cases of R. parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States.
UR - http://www.scopus.com/inward/record.url?scp=1642325810&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642325810&partnerID=8YFLogxK
U2 - 10.1086/381894
DO - 10.1086/381894
M3 - Article
C2 - 14999622
AN - SCOPUS:1642325810
SN - 1058-4838
VL - 38
SP - 805
EP - 811
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 6
ER -