Rickettsiales: Treatment and management of human disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

When a rickettsiosis is suspected, prompt empiric antibiotic therapy should be initiated. Clinical recognition is key to timely treatment. Early administration of effective antibiotics can quickly abate illness and prevent severe complications. Tetracyclines are the drug class of choice for all these infections, with doxycycline being the preferred agent. Where available, chloramphenicol can be used for spotted fever group rickettsioses, typhus group rickettsioses, and scrub typhus, but the drug is not effective for infections caused by Ehrlichia spp. and Anaplasma phagocytophilum. Other alternative agents are available, but their efficacy against the different genera of this order is not as generalizable as that of tetracyclines.

Original languageEnglish (US)
Title of host publicationRickettsiales
Subtitle of host publicationBiology, Molecular Biology, Epidemiology, and Vaccine Development
PublisherSpringer International Publishing
Pages109-124
Number of pages16
ISBN (Electronic)9783319468594
ISBN (Print)9783319468570
DOIs
StatePublished - Jan 1 2016

Keywords

  • Anaplasmosis
  • Azithromycin
  • Chloramphenicol
  • Doxycycline
  • Ehrlichiosis
  • Fluoroquinolones
  • Rifampin
  • Scrub typhus
  • Spotted fever group rickettsioses
  • Typhus group rickettsioses

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Blanton, L. S. (2016). Rickettsiales: Treatment and management of human disease. In Rickettsiales: Biology, Molecular Biology, Epidemiology, and Vaccine Development (pp. 109-124). Springer International Publishing. https://doi.org/10.1007/978-3-319-46859-4_5