Rickettsioses of the spotted fever group around the world

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41 Citations (Scopus)

Abstract

Spotted fever group rickettsioses comprise Rocky Mountain spotted fever (Rickettsia rickettsii), boutonneuse fever (R. conorii), North Asian tick typhus (R. sibirica), Queensland tick typhus (R. australis), rickettsialpox (R. akari), and Oriental spotted fever (R. japonica). Ticks or mites serve as the vector and reservoir hosts of the rickettsiae. These obligate intracellular bacteria invade vascular endothelial cells, which are damaged directly, causing increased vascular permeability. The rash usually appears in Rocky Mountain spotted fever on the third day of illness and later evolves to become petechial maculopapules in 50% of cases with involvement of the palms and soles in a similar proportion of patients. Eschar occurs in some SFG rickettsioses at the site of tick bite, but rarely in Rocky Mountain spotted fever. Diagnosis often proves difficult, and laboratory assays for antibodies to SFG rickettsiae are generaly useful only in convalescence. Rickettsiae are demonstrable by diagnostic immunohistology in biopsies of rash or eschar. Empiric treatment with doxycycline, tetracycline, or chloramphenicol should be given early in the course on the basis of clinical suspicion of the diagnosis of a SFG rickettsiosis.

Original languageEnglish (US)
Pages (from-to)169-177
Number of pages9
JournalJournal of Dermatology
Volume16
Issue number3
StatePublished - 1989

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Rocky Mountain Spotted Fever
Rickettsia
Ticks
Epidemic Louse-Borne Typhus
Fever
Exanthema
Rickettsiaceae Infections
Rickettsia rickettsii
Boutonneuse Fever
Tick Bites
Sick Leave
Queensland
Doxycycline
Mites
Capillary Permeability
Chloramphenicol
Tetracycline
Endothelial Cells
Bacteria
Biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Rickettsioses of the spotted fever group around the world. / Walker, David.

In: Journal of Dermatology, Vol. 16, No. 3, 1989, p. 169-177.

Research output: Contribution to journalArticle

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abstract = "Spotted fever group rickettsioses comprise Rocky Mountain spotted fever (Rickettsia rickettsii), boutonneuse fever (R. conorii), North Asian tick typhus (R. sibirica), Queensland tick typhus (R. australis), rickettsialpox (R. akari), and Oriental spotted fever (R. japonica). Ticks or mites serve as the vector and reservoir hosts of the rickettsiae. These obligate intracellular bacteria invade vascular endothelial cells, which are damaged directly, causing increased vascular permeability. The rash usually appears in Rocky Mountain spotted fever on the third day of illness and later evolves to become petechial maculopapules in 50{\%} of cases with involvement of the palms and soles in a similar proportion of patients. Eschar occurs in some SFG rickettsioses at the site of tick bite, but rarely in Rocky Mountain spotted fever. Diagnosis often proves difficult, and laboratory assays for antibodies to SFG rickettsiae are generaly useful only in convalescence. Rickettsiae are demonstrable by diagnostic immunohistology in biopsies of rash or eschar. Empiric treatment with doxycycline, tetracycline, or chloramphenicol should be given early in the course on the basis of clinical suspicion of the diagnosis of a SFG rickettsiosis.",
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