Rift valley fever infection of rhesus monkeys: Implications for rapid diagnosis of human disease

J. C. Morrill, F. K. Knauert, T. G. Ksiazek, J. M. Meegan, C. J. Peters

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalResearch in Virology
Volume140
Issue numberC
DOIs
StatePublished - 1989

Keywords

  • DNA hybridization
  • ELISA
  • Models
  • RVF
  • Rhesus monkey

ASJC Scopus subject areas

  • Immunology
  • Virology

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