Rift valley fever infection of rhesus monkeys

Implications for rapid diagnosis of human disease

J. C. Morrill, F. K. Knauert, Thomas Ksiazek, J. M. Meegan, C. J. Peters

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rhesus monkeys inoculated with Rift Valley fever (RVF) virus provide a model in which serial observations of serum viral antigen and antibodies can be made. In 9 non-fatal and 3 fatal infections, either antigen or IgM enzymelinked immunosorbent assay (ELISA) antibodies were detected in every serum sample during the acute phase. Furthermore, viral nucleic acid could be detected by filter hybridization in most samples taken on days 1 to 3. Circulation of significant quantities of viral RNA provides an additional approach to the diagnosis and study of RVF.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalResearch in Virology
Volume140
Issue numberC
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Rift Valley Fever
Macaca mulatta
Rift Valley fever virus
Viral Antibodies
Immunosorbents
Viral Antigens
Viral RNA
Infection
Serum
Nucleic Acids
Immunoglobulin M
Antigens
Antibodies

Keywords

  • DNA hybridization
  • ELISA
  • Models
  • Rhesus monkey
  • RVF

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Rift valley fever infection of rhesus monkeys : Implications for rapid diagnosis of human disease. / Morrill, J. C.; Knauert, F. K.; Ksiazek, Thomas; Meegan, J. M.; Peters, C. J.

In: Research in Virology, Vol. 140, No. C, 1989, p. 139-146.

Research output: Contribution to journalArticle

Morrill, J. C. ; Knauert, F. K. ; Ksiazek, Thomas ; Meegan, J. M. ; Peters, C. J. / Rift valley fever infection of rhesus monkeys : Implications for rapid diagnosis of human disease. In: Research in Virology. 1989 ; Vol. 140, No. C. pp. 139-146.
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