RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction

Nandadeva Lokugamage; Allison Wyrick; Subhadip Choudhuri; Maher Raja; Imran Chowdhury; Siddhartha De; Upendra Marathi; Nisha Jain Garg

doi:10.1016/j.jacbts.2026.101508

RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction

Nandadeva Lokugamage
, Allison Wyrick
, Subhadip Choudhuri
, Maher Raja
, Imran Chowdhury
, Siddhartha De
, Upendra Marathi
, Nisha Jain Garg

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi . Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.

Original language	English (US)
Article number	101508
Journal	JACC: Basic to Translational Science
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/j.jacbts.2026.101508
State	Published - Mar 2026

Keywords

antibody and T cell response
bicistronic immunogen
Chagas disease
heart function
Trypanosoma cruzi

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2026.101508

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title = "RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction",

abstract = "BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi . Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.",

keywords = "antibody and T cell response, bicistronic immunogen, Chagas disease, heart function, Trypanosoma cruzi",

author = "Nandadeva Lokugamage and Allison Wyrick and Subhadip Choudhuri and Maher Raja and Imran Chowdhury and Siddhartha De and Upendra Marathi and Garg, \{Nisha Jain\}",

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year = "2026",

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doi = "10.1016/j.jacbts.2026.101508",

language = "English (US)",

volume = "11",

journal = "JACC: Basic to Translational Science",

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T1 - RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction

AU - Lokugamage, Nandadeva

AU - Wyrick, Allison

AU - Choudhuri, Subhadip

AU - Raja, Maher

AU - Chowdhury, Imran

AU - De, Siddhartha

AU - Marathi, Upendra

AU - Garg, Nisha Jain

PY - 2026/3

Y1 - 2026/3

N2 - BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi . Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.

AB - BCVR and BCV (bicistronic immunogen with and without RIG-I adjuvant) immunogens were designed in compliance with Food and Drug Administration guidelines. These immunogens were nontoxic, and highly effective in controlling the replication and persistence of Trypanosoma cruzi . Importantly, BCV/BCVR blocked the myocarditis, cardiac fibrosis, and left ventricular dysfunction that otherwise contribute to heart failure and sudden death in Chagas disease.

KW - antibody and T cell response

KW - bicistronic immunogen

KW - Chagas disease

KW - heart function

KW - Trypanosoma cruzi

UR - https://www.scopus.com/pages/publications/105032560889

UR - https://www.scopus.com/pages/publications/105032560889#tab=citedBy

U2 - 10.1016/j.jacbts.2026.101508

DO - 10.1016/j.jacbts.2026.101508

M3 - Article

C2 - 42018143

AN - SCOPUS:105032560889

SN - 2452-302X

VL - 11

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 3

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ER -

RIG-I–Adjuvanted Immunogen Elicited T-Cell Immunity Controls Trypanosoma cruzi, Chagasic Cardiomyopathy, and Left Ventricular Dysfunction

Abstract

Keywords

ASJC Scopus subject areas

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