Right bundle branch block

a predictor of mortality in early systemic sclerosis.

Hilda T. Draeger, Shervin Assassi, Roozbeh Sharif, Emilio Gonzalez, Brock E. Harper, Frank C. Arnett, Ameena Manzoor, Richard A. Lange, Maureen D. Mayes

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To evaluate the prognostic significance of baseline electrocardiogram (ECG) abnormalities in a multiethnic cohort of patients with early systemic sclerosis (SSc) and to determine the serological, clinical, and echocardiogram correlates of ECG findings. SSc patients with disease duration of≤5 years were enrolled in the GENISOS (Genetics versus Environment in Scleroderma Outcome Study) cohort. At the first visit, a standard 12 lead ECG was obtained along with demographic information, clinical data, and autoantibodies. The results of echocardiograms were also recorded. All ECGs were interpreted by a cardiologist unaware of the patients' clinical data. Of 265 SSc patients with average disease duration at enrollment of 2.5 years, 140 (52.8%) had abnormal ECG findings. These findings were not associated with SSc disease type or autoantibody profile but were associated with more severe heart and lung involvement. A total of 75 patients (28.3%) died over a follow up time of 9.9 years. Complete right bundle branch block (± left anterior hemiblock) on ECG, present in 7 (2.6%) patients, predicted a higher risk of mortality (HR: 5.3; 95% CI: 2.1 to 13.4; p<0.001). The predictive significance of right bundle branch block was independent of age at enrollment, gender, ethnicity and risk factors for coronary artery disease. ECG abnormalities are common in patients with early SSc and are associated with the severity of lung and heart involvement. Right bundle branch block is an independent predictor of mortality, and should be considered a marker of disease severity in SSc.

Original languageEnglish (US)
Article numbere78808
JournalPLoS One
Volume8
Issue number10
StatePublished - 2013
Externally publishedYes

Fingerprint

Bundle-Branch Block
Systemic Scleroderma
sclerosis
Electrocardiography
electrocardiography
Mortality
autoantibodies
Autoantibodies
lungs
heart
Lung
duration
nationalities and ethnic groups
cohort studies
disease severity
Coronary Artery Disease
risk factors
demographic statistics
Demography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Draeger, H. T., Assassi, S., Sharif, R., Gonzalez, E., Harper, B. E., Arnett, F. C., ... Mayes, M. D. (2013). Right bundle branch block: a predictor of mortality in early systemic sclerosis. PLoS One, 8(10), [e78808].

Right bundle branch block : a predictor of mortality in early systemic sclerosis. / Draeger, Hilda T.; Assassi, Shervin; Sharif, Roozbeh; Gonzalez, Emilio; Harper, Brock E.; Arnett, Frank C.; Manzoor, Ameena; Lange, Richard A.; Mayes, Maureen D.

In: PLoS One, Vol. 8, No. 10, e78808, 2013.

Research output: Contribution to journalArticle

Draeger, HT, Assassi, S, Sharif, R, Gonzalez, E, Harper, BE, Arnett, FC, Manzoor, A, Lange, RA & Mayes, MD 2013, 'Right bundle branch block: a predictor of mortality in early systemic sclerosis.', PLoS One, vol. 8, no. 10, e78808.
Draeger HT, Assassi S, Sharif R, Gonzalez E, Harper BE, Arnett FC et al. Right bundle branch block: a predictor of mortality in early systemic sclerosis. PLoS One. 2013;8(10). e78808.
Draeger, Hilda T. ; Assassi, Shervin ; Sharif, Roozbeh ; Gonzalez, Emilio ; Harper, Brock E. ; Arnett, Frank C. ; Manzoor, Ameena ; Lange, Richard A. ; Mayes, Maureen D. / Right bundle branch block : a predictor of mortality in early systemic sclerosis. In: PLoS One. 2013 ; Vol. 8, No. 10.
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