Risk factors and outcomes of pancreatitis after open heart surgery

Alexander Perez, Hiromichi Ito, Robert S. Farivar, Lawrence H. Cohn, John G. Byrne, James D. Rawn, Sary F. Aranki, Michael J. Zinner, Nicholas L. Tilney, David C. Brooks, Stanley W. Ashley, Peter A. Banks, Edward E. Whang

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Background: We sought to analyze the risk factors and natural history associated with post-cardiac surgery acute pancreatitis. Methods: Retrospective analysis of all patients having undergone cardiac surgery at our hospital between January 1, 1992, and October 1, 2001. Results: A total of 10,249 cardiac operations were performed. Thirty-nine (0.4%) patients developed postoperative pancreatitis. There was a higher incidence during the period spanning 1992 through 1996 than 1997 through 2001 (0.6% versus 0.2%, P < .05). Patients with pancreatitis had longer postoperative length of stay (51 ± 5 days versus 10 ± 1 days, P < .05) and a greater in-hospital mortality rate (28% versus 4%, P < .05) than patients who did not develop pancreatitis. A history of alcohol abuse, cardiac surgery performed during 1992 to 1996, increased cardiopulmonary bypass time, and increased cross-clamp time were independent risk factors for the development of pancreatitis. Multiple-organ failure was an independent predictor for death among patients with pancreatitis. Conclusions: Although the frequency of post-cardiac surgery pancreatitis is diminishing, it is still associated with significant mortality.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalAmerican Journal of Surgery
Volume190
Issue number3
DOIs
StatePublished - Sep 2005
Externally publishedYes

Keywords

  • Acute pancreatitis
  • Cardiac surgery

ASJC Scopus subject areas

  • Surgery

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    Perez, A., Ito, H., Farivar, R. S., Cohn, L. H., Byrne, J. G., Rawn, J. D., Aranki, S. F., Zinner, M. J., Tilney, N. L., Brooks, D. C., Ashley, S. W., Banks, P. A., & Whang, E. E. (2005). Risk factors and outcomes of pancreatitis after open heart surgery. American Journal of Surgery, 190(3), 401-405. https://doi.org/10.1016/j.amjsurg.2005.03.004