Risk factors for anal dysplasia among privately insured HIV-negative women

Ana M. Rodriguez, Ana C. Rodriguez, Yu Li Lin, Burak Zeybek, Kathleen M. Schmeler, Yong Fang Kuo

Research output: Contribution to journalArticle

Abstract

Objective: To examine the relationship between anogenital abnormalities and the development of anal dysplasia
among Human Immunodeficiency Virus (HIV)-negative women.
Methods: This retrospective matched case-control study used administrative data from the 2009-2014 Clinformatics
Data Mart. Cases were selected according to the International Classification of Diseases, Ninth Revision, using Clinical
Modification codes for carcinoma in situ of the anal canal or anus unspecified, anal intraepithelial neoplasia 1 and 2,
abnormal glandular Papanicolaou (Pap) smear of the anus, or Pap smears of the anus with atypical squamous cells,
squamous intraepithelial lesions, or cytological evidence of malignancy. Conditional logistic regression analysis was
used to calculate odds ratios (ORs) and 95% confidence intervals for the risk of anal dysplasia.
Results: The study included 3,384 HIV-negative women (846 cases and 2,538 controls), mean age 50.1 ± 11.9
years. The odds of being a smoker, having cervical intraepithelial neoplasia (CIN), or anogenital warts were higher for
HIV-negative women with anal dysplasia than for those without anal dysplasia (OR =2.5-16.3).
Conclusions: HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus
(HPV)-related CIN and anogenital warts than women without anal dysplasia. The presence of HPV-associated lesions
might have implications for future screening recommendations. HIV-negative women with a history of CIN and anogenital
warts could benefit from anal dysplasia/anal cancer screening. Gaining a better understanding of the natural history of
anal HPV infections will provide tools to better treat and counsel patients with anal dysplasia.
Original languageEnglish (US)
Pages (from-to)108
Number of pages5
JournalJournal of Cancer Research and Immuno-Oncology
Volume3
Issue number1
DOIs
StateAccepted/In press - 2017

Fingerprint

Anal Canal
HIV
Papanicolaou Test
Cervical Intraepithelial Neoplasia
Warts
Odds Ratio
Anus Neoplasms
Papillomavirus Infections
Carcinoma in Situ
International Classification of Diseases
Natural History
Early Detection of Cancer
Case-Control Studies
Neoplasms
Logistic Models
Regression Analysis
Confidence Intervals

Keywords

  • anal dysplasia
  • anal intraepithelial neoplasia
  • cervical cytology
  • anogenital warts
  • Cervical intraepithelial neoplasia
  • HPV
  • Anal cancer

Cite this

Risk factors for anal dysplasia among privately insured HIV-negative women. / Rodriguez, Ana M.; Rodriguez, Ana C.; Lin, Yu Li; Zeybek, Burak; Schmeler, Kathleen M.; Kuo, Yong Fang.

In: Journal of Cancer Research and Immuno-Oncology, Vol. 3, No. 1, 2017, p. 108.

Research output: Contribution to journalArticle

Rodriguez, Ana M. ; Rodriguez, Ana C. ; Lin, Yu Li ; Zeybek, Burak ; Schmeler, Kathleen M. ; Kuo, Yong Fang. / Risk factors for anal dysplasia among privately insured HIV-negative women. In: Journal of Cancer Research and Immuno-Oncology. 2017 ; Vol. 3, No. 1. pp. 108.
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abstract = "Objective: To examine the relationship between anogenital abnormalities and the development of anal dysplasiaamong Human Immunodeficiency Virus (HIV)-negative women.Methods: This retrospective matched case-control study used administrative data from the 2009-2014 ClinformaticsData Mart. Cases were selected according to the International Classification of Diseases, Ninth Revision, using ClinicalModification codes for carcinoma in situ of the anal canal or anus unspecified, anal intraepithelial neoplasia 1 and 2,abnormal glandular Papanicolaou (Pap) smear of the anus, or Pap smears of the anus with atypical squamous cells,squamous intraepithelial lesions, or cytological evidence of malignancy. Conditional logistic regression analysis wasused to calculate odds ratios (ORs) and 95{\%} confidence intervals for the risk of anal dysplasia.Results: The study included 3,384 HIV-negative women (846 cases and 2,538 controls), mean age 50.1 ± 11.9years. The odds of being a smoker, having cervical intraepithelial neoplasia (CIN), or anogenital warts were higher forHIV-negative women with anal dysplasia than for those without anal dysplasia (OR =2.5-16.3).Conclusions: HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus(HPV)-related CIN and anogenital warts than women without anal dysplasia. The presence of HPV-associated lesionsmight have implications for future screening recommendations. HIV-negative women with a history of CIN and anogenitalwarts could benefit from anal dysplasia/anal cancer screening. Gaining a better understanding of the natural history ofanal HPV infections will provide tools to better treat and counsel patients with anal dysplasia.",
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N2 - Objective: To examine the relationship between anogenital abnormalities and the development of anal dysplasiaamong Human Immunodeficiency Virus (HIV)-negative women.Methods: This retrospective matched case-control study used administrative data from the 2009-2014 ClinformaticsData Mart. Cases were selected according to the International Classification of Diseases, Ninth Revision, using ClinicalModification codes for carcinoma in situ of the anal canal or anus unspecified, anal intraepithelial neoplasia 1 and 2,abnormal glandular Papanicolaou (Pap) smear of the anus, or Pap smears of the anus with atypical squamous cells,squamous intraepithelial lesions, or cytological evidence of malignancy. Conditional logistic regression analysis wasused to calculate odds ratios (ORs) and 95% confidence intervals for the risk of anal dysplasia.Results: The study included 3,384 HIV-negative women (846 cases and 2,538 controls), mean age 50.1 ± 11.9years. The odds of being a smoker, having cervical intraepithelial neoplasia (CIN), or anogenital warts were higher forHIV-negative women with anal dysplasia than for those without anal dysplasia (OR =2.5-16.3).Conclusions: HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus(HPV)-related CIN and anogenital warts than women without anal dysplasia. The presence of HPV-associated lesionsmight have implications for future screening recommendations. HIV-negative women with a history of CIN and anogenitalwarts could benefit from anal dysplasia/anal cancer screening. Gaining a better understanding of the natural history ofanal HPV infections will provide tools to better treat and counsel patients with anal dysplasia.

AB - Objective: To examine the relationship between anogenital abnormalities and the development of anal dysplasiaamong Human Immunodeficiency Virus (HIV)-negative women.Methods: This retrospective matched case-control study used administrative data from the 2009-2014 ClinformaticsData Mart. Cases were selected according to the International Classification of Diseases, Ninth Revision, using ClinicalModification codes for carcinoma in situ of the anal canal or anus unspecified, anal intraepithelial neoplasia 1 and 2,abnormal glandular Papanicolaou (Pap) smear of the anus, or Pap smears of the anus with atypical squamous cells,squamous intraepithelial lesions, or cytological evidence of malignancy. Conditional logistic regression analysis wasused to calculate odds ratios (ORs) and 95% confidence intervals for the risk of anal dysplasia.Results: The study included 3,384 HIV-negative women (846 cases and 2,538 controls), mean age 50.1 ± 11.9years. The odds of being a smoker, having cervical intraepithelial neoplasia (CIN), or anogenital warts were higher forHIV-negative women with anal dysplasia than for those without anal dysplasia (OR =2.5-16.3).Conclusions: HIV-negative women with anal dysplasia are more likely to have concomitant human papillomavirus(HPV)-related CIN and anogenital warts than women without anal dysplasia. The presence of HPV-associated lesionsmight have implications for future screening recommendations. HIV-negative women with a history of CIN and anogenitalwarts could benefit from anal dysplasia/anal cancer screening. Gaining a better understanding of the natural history ofanal HPV infections will provide tools to better treat and counsel patients with anal dysplasia.

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