Risk factors for encephalitis and death from West Nile virus infection

Kristy O. Murray, S. Baraniuk, M. Resnick, R. Arafat, C. Kilborn, K. Cain, R. Shallenberger, T. L. York, D. Martinez, J. S. Hellums, D. Hellums, M. Malkoff, N. Elgawley, W. McNeely, S. A. Khuwaja, R. B. Tesh

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

We conducted a nested case-control study to determine potential risk factors for developing encephalitis from West Nile virus (WNV) infection. Retrospective medical chart reviews were completed for 172 confirmed WNV cases hospitalized in Houston between 2002 and 2004. Of these cases, 113 had encephalitis, including 17 deaths, 47 had meningitis, and 12 were fever cases; 67% were male. Homeless patients were more likely to be hospitalized from WNV compared to the general population. A multiple logistic regression model identified age [odds ratio (OR) 1.1, P<0·001], history of hypertension, including those cases taking hypertension-inducing drugs (OR 2·9, P = 0·012), and history of cardiovascular disease (OR 3·5, P = 0·061) as independent risk factors for developing encephalitis from WNV infection. After adjusting for age, race/ethnicity (being black) (OR 12·0, P<0·001), chronic renal disease (OR 10·6, P<0·001), hepatitis C virus (OR 23·1, P = 0·0013), and immunosuppression (OR 3·9, P = 0·033) were identified as risk factors for death from WNV infection.

Original languageEnglish (US)
Pages (from-to)1325-1332
Number of pages8
JournalEpidemiology and Infection
Volume134
Issue number6
DOIs
StatePublished - Dec 2006

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West Nile virus
Virus Diseases
Encephalitis
Odds Ratio
Logistic Models
Hypertension
Chronic Renal Insufficiency
Meningitis
Hepacivirus
Immunosuppression
Case-Control Studies
Fever
Cardiovascular Diseases
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Murray, K. O., Baraniuk, S., Resnick, M., Arafat, R., Kilborn, C., Cain, K., ... Tesh, R. B. (2006). Risk factors for encephalitis and death from West Nile virus infection. Epidemiology and Infection, 134(6), 1325-1332. https://doi.org/10.1017/S0950268806006339

Risk factors for encephalitis and death from West Nile virus infection. / Murray, Kristy O.; Baraniuk, S.; Resnick, M.; Arafat, R.; Kilborn, C.; Cain, K.; Shallenberger, R.; York, T. L.; Martinez, D.; Hellums, J. S.; Hellums, D.; Malkoff, M.; Elgawley, N.; McNeely, W.; Khuwaja, S. A.; Tesh, R. B.

In: Epidemiology and Infection, Vol. 134, No. 6, 12.2006, p. 1325-1332.

Research output: Contribution to journalArticle

Murray, KO, Baraniuk, S, Resnick, M, Arafat, R, Kilborn, C, Cain, K, Shallenberger, R, York, TL, Martinez, D, Hellums, JS, Hellums, D, Malkoff, M, Elgawley, N, McNeely, W, Khuwaja, SA & Tesh, RB 2006, 'Risk factors for encephalitis and death from West Nile virus infection', Epidemiology and Infection, vol. 134, no. 6, pp. 1325-1332. https://doi.org/10.1017/S0950268806006339
Murray KO, Baraniuk S, Resnick M, Arafat R, Kilborn C, Cain K et al. Risk factors for encephalitis and death from West Nile virus infection. Epidemiology and Infection. 2006 Dec;134(6):1325-1332. https://doi.org/10.1017/S0950268806006339
Murray, Kristy O. ; Baraniuk, S. ; Resnick, M. ; Arafat, R. ; Kilborn, C. ; Cain, K. ; Shallenberger, R. ; York, T. L. ; Martinez, D. ; Hellums, J. S. ; Hellums, D. ; Malkoff, M. ; Elgawley, N. ; McNeely, W. ; Khuwaja, S. A. ; Tesh, R. B. / Risk factors for encephalitis and death from West Nile virus infection. In: Epidemiology and Infection. 2006 ; Vol. 134, No. 6. pp. 1325-1332.
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