Risk factors for gallbladder cancer

An International Collaborative Case- Control Study

B. L. Strom, R. D. Soloway, J. L. Rios-Dalenz, H. A. Rodriguez-Martinez, S. L. West, J. L. Kinman, M. Polansky, J. A. Berlin

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Background. Gallbladder cancer has an unusual geographic and demographic distribution, suggesting many possible etiologies. Methods. A case-control study was undertaken at four hospitals in La Paz, Bolivia, and at one hospital in Mexico City, Mexico. Eighty-four patients with newly diagnosed, histologically confirmed gallbladder cancer were compared with 126 control subjects without stones and with 264 control subjects with cholelithiasis or choledocholithiasis without cancer. All study subjects underwent abdominal surgery. Study subjects were interviewed regarding demographic characteristics, medical history, family history, diet, and exposure to agents presumed to be risk factors for biliary cancer. Results. Virtually all subjects in Mexico were judged to be mestizos (i.e., persons of mixed ancestry). In contrast, race was a very strong risk factor for gallbladder cancer in Bolivia. Relative to mestizos who spoke neither language, the odds ratio (95% confidence interval [CI]) for cases versus control subjects without stones for those who spoke Aymara well was 15.9 (CI, 1.9-179), whereas it was 1.4 (CI, 0.2-8.2) for those who spoke Quechua well. An increased risk was also noted for elevated maximum body mass index (P = 0.03), family history of gallstones (odds ratio [OR] = 3.6 [CI, 1.3-11.4]), and physician-diagnosed typhoid (OR = 12.7 [CI, 1.5-598]). An increased risk was also seen with elevated maximum body mass index; compared with those with a body mass index less than 24 kg/m2, those with an index of 24-25 kg/m2, 26-28 kg/m2, and greater than 28 kg/m2 had odds ratios of 1.6 (CI, 0.47.6). 1.3 (CI. 0.3-5.6), and 2.6 (CI, 0.5-18.6), respectively (asymptotic test for trend, P = 0.03). Finally, a number of associations were noted with certain dietary and cooking habits. Conclusions. Patients with gallbladder cancer differed from control subjects in race, body mass, physician-diagnosed typhoid, and certain dietary patterns. These findings may provide useful clues to the pathogenesis of gallbladder cancer, but given the number of analyses performed, additional cases need to be studied.

Original languageEnglish (US)
Pages (from-to)1747-1756
Number of pages10
JournalCancer
Volume76
Issue number10
DOIs
StatePublished - 1995
Externally publishedYes

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Gallbladder Neoplasms
Case-Control Studies
Confidence Intervals
Mexico
Odds Ratio
Bolivia
Body Mass Index
Typhoid Fever
Medical History Taking
Demography
Biliary Tract Neoplasms
Physicians
Choledocholithiasis
Cholelithiasis
Cooking
Gallstones
Feeding Behavior
Language
Diet

Keywords

  • case-control study
  • diet
  • gallbladder cancer
  • obesity
  • occupation
  • race
  • typhoid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Strom, B. L., Soloway, R. D., Rios-Dalenz, J. L., Rodriguez-Martinez, H. A., West, S. L., Kinman, J. L., ... Berlin, J. A. (1995). Risk factors for gallbladder cancer: An International Collaborative Case- Control Study. Cancer, 76(10), 1747-1756. https://doi.org/10.1002/1097-0142(19951115)76:10<1747::AID-CNCR2820761011>3.0.CO;2-L

Risk factors for gallbladder cancer : An International Collaborative Case- Control Study. / Strom, B. L.; Soloway, R. D.; Rios-Dalenz, J. L.; Rodriguez-Martinez, H. A.; West, S. L.; Kinman, J. L.; Polansky, M.; Berlin, J. A.

In: Cancer, Vol. 76, No. 10, 1995, p. 1747-1756.

Research output: Contribution to journalArticle

Strom, BL, Soloway, RD, Rios-Dalenz, JL, Rodriguez-Martinez, HA, West, SL, Kinman, JL, Polansky, M & Berlin, JA 1995, 'Risk factors for gallbladder cancer: An International Collaborative Case- Control Study', Cancer, vol. 76, no. 10, pp. 1747-1756. https://doi.org/10.1002/1097-0142(19951115)76:10<1747::AID-CNCR2820761011>3.0.CO;2-L
Strom, B. L. ; Soloway, R. D. ; Rios-Dalenz, J. L. ; Rodriguez-Martinez, H. A. ; West, S. L. ; Kinman, J. L. ; Polansky, M. ; Berlin, J. A. / Risk factors for gallbladder cancer : An International Collaborative Case- Control Study. In: Cancer. 1995 ; Vol. 76, No. 10. pp. 1747-1756.
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abstract = "Background. Gallbladder cancer has an unusual geographic and demographic distribution, suggesting many possible etiologies. Methods. A case-control study was undertaken at four hospitals in La Paz, Bolivia, and at one hospital in Mexico City, Mexico. Eighty-four patients with newly diagnosed, histologically confirmed gallbladder cancer were compared with 126 control subjects without stones and with 264 control subjects with cholelithiasis or choledocholithiasis without cancer. All study subjects underwent abdominal surgery. Study subjects were interviewed regarding demographic characteristics, medical history, family history, diet, and exposure to agents presumed to be risk factors for biliary cancer. Results. Virtually all subjects in Mexico were judged to be mestizos (i.e., persons of mixed ancestry). In contrast, race was a very strong risk factor for gallbladder cancer in Bolivia. Relative to mestizos who spoke neither language, the odds ratio (95{\%} confidence interval [CI]) for cases versus control subjects without stones for those who spoke Aymara well was 15.9 (CI, 1.9-179), whereas it was 1.4 (CI, 0.2-8.2) for those who spoke Quechua well. An increased risk was also noted for elevated maximum body mass index (P = 0.03), family history of gallstones (odds ratio [OR] = 3.6 [CI, 1.3-11.4]), and physician-diagnosed typhoid (OR = 12.7 [CI, 1.5-598]). An increased risk was also seen with elevated maximum body mass index; compared with those with a body mass index less than 24 kg/m2, those with an index of 24-25 kg/m2, 26-28 kg/m2, and greater than 28 kg/m2 had odds ratios of 1.6 (CI, 0.47.6). 1.3 (CI. 0.3-5.6), and 2.6 (CI, 0.5-18.6), respectively (asymptotic test for trend, P = 0.03). Finally, a number of associations were noted with certain dietary and cooking habits. Conclusions. Patients with gallbladder cancer differed from control subjects in race, body mass, physician-diagnosed typhoid, and certain dietary patterns. These findings may provide useful clues to the pathogenesis of gallbladder cancer, but given the number of analyses performed, additional cases need to be studied.",
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N2 - Background. Gallbladder cancer has an unusual geographic and demographic distribution, suggesting many possible etiologies. Methods. A case-control study was undertaken at four hospitals in La Paz, Bolivia, and at one hospital in Mexico City, Mexico. Eighty-four patients with newly diagnosed, histologically confirmed gallbladder cancer were compared with 126 control subjects without stones and with 264 control subjects with cholelithiasis or choledocholithiasis without cancer. All study subjects underwent abdominal surgery. Study subjects were interviewed regarding demographic characteristics, medical history, family history, diet, and exposure to agents presumed to be risk factors for biliary cancer. Results. Virtually all subjects in Mexico were judged to be mestizos (i.e., persons of mixed ancestry). In contrast, race was a very strong risk factor for gallbladder cancer in Bolivia. Relative to mestizos who spoke neither language, the odds ratio (95% confidence interval [CI]) for cases versus control subjects without stones for those who spoke Aymara well was 15.9 (CI, 1.9-179), whereas it was 1.4 (CI, 0.2-8.2) for those who spoke Quechua well. An increased risk was also noted for elevated maximum body mass index (P = 0.03), family history of gallstones (odds ratio [OR] = 3.6 [CI, 1.3-11.4]), and physician-diagnosed typhoid (OR = 12.7 [CI, 1.5-598]). An increased risk was also seen with elevated maximum body mass index; compared with those with a body mass index less than 24 kg/m2, those with an index of 24-25 kg/m2, 26-28 kg/m2, and greater than 28 kg/m2 had odds ratios of 1.6 (CI, 0.47.6). 1.3 (CI. 0.3-5.6), and 2.6 (CI, 0.5-18.6), respectively (asymptotic test for trend, P = 0.03). Finally, a number of associations were noted with certain dietary and cooking habits. Conclusions. Patients with gallbladder cancer differed from control subjects in race, body mass, physician-diagnosed typhoid, and certain dietary patterns. These findings may provide useful clues to the pathogenesis of gallbladder cancer, but given the number of analyses performed, additional cases need to be studied.

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