Risk factors for multiple intracranial aneurysms

Adnan I. Qureshi, Jose I. Suarez, Parag D. Parekh, Gene Sung, Romergryko Geocadin, Anish Bhardwaj, Rafael J. Tamargo, John A. Ulatowski

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

OBJECTIVE: Risk factors that predispose to the formation of multiple intracranial aneurysms, which are present in up to 34% of patients with intracranial aneurysms, are not well defined. In this study, we examined the association between known risk factors for cerebrovascular disease and presence of multiple intracranial aneurysms. METHODS: We reviewed the medical records and results of conventional angiography in all patients with a diagnosis of intracranial aneurysms admitted to the Johns Hopkins University hospital between January 1990 and June 1997. We determined the independent association between various cerebrovascular risk factors and the presence of multiple aneurysms using logistic regression analysis. RESULTS: Of 419 patients admitted with intracranial aneurysms (298 ruptured and 121 unruptured), 127 (30%) had multiple intracranial aneurysms. In univariate analysis, female gender (odds ratio [OR] = 1.9; 95% confidence interval [CI], 1.1-3.3) and cigarette smoking at any time (OR = 1.8; 95% CI, 1.1-3.0) were significantly associated with presence of multiple aneurysms. In the multivariate analysis, cigarette smoking at any time (OR = 1.7; 95% CI, 1.1- 2.8) and female gender (OR = 2.1; 95% CI 1.2-3.5) remained significantly associated with multiple aneurysms. Hypertension, diabetes mellitus, and alcohol and illicit drug use were not significantly associated with presence of multiple aneurysms. CONCLUSION: Cigarette smoking and female gender seem to increase the risk for multiple aneurysms in patients predisposed to intracranial aneurysm formation. Further studies are required to investigate the mechanism underlying the association between cigarette smoking and intracranial aneurysm formation.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalNeurosurgery
Volume43
Issue number1
DOIs
StatePublished - Jul 1998
Externally publishedYes

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Intracranial Aneurysm
Aneurysm
Smoking
Odds Ratio
Confidence Intervals
Cerebrovascular Disorders
Street Drugs
Medical Records
Diabetes Mellitus
Angiography
Multivariate Analysis
Logistic Models
Regression Analysis
Alcohols
Hypertension

Keywords

  • Aneurysms
  • Cigarette smoking
  • Gender
  • Hypertension

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Qureshi, A. I., Suarez, J. I., Parekh, P. D., Sung, G., Geocadin, R., Bhardwaj, A., ... Ulatowski, J. A. (1998). Risk factors for multiple intracranial aneurysms. Neurosurgery, 43(1), 22-27. https://doi.org/10.1097/00006123-199807000-00013

Risk factors for multiple intracranial aneurysms. / Qureshi, Adnan I.; Suarez, Jose I.; Parekh, Parag D.; Sung, Gene; Geocadin, Romergryko; Bhardwaj, Anish; Tamargo, Rafael J.; Ulatowski, John A.

In: Neurosurgery, Vol. 43, No. 1, 07.1998, p. 22-27.

Research output: Contribution to journalArticle

Qureshi, AI, Suarez, JI, Parekh, PD, Sung, G, Geocadin, R, Bhardwaj, A, Tamargo, RJ & Ulatowski, JA 1998, 'Risk factors for multiple intracranial aneurysms', Neurosurgery, vol. 43, no. 1, pp. 22-27. https://doi.org/10.1097/00006123-199807000-00013
Qureshi AI, Suarez JI, Parekh PD, Sung G, Geocadin R, Bhardwaj A et al. Risk factors for multiple intracranial aneurysms. Neurosurgery. 1998 Jul;43(1):22-27. https://doi.org/10.1097/00006123-199807000-00013
Qureshi, Adnan I. ; Suarez, Jose I. ; Parekh, Parag D. ; Sung, Gene ; Geocadin, Romergryko ; Bhardwaj, Anish ; Tamargo, Rafael J. ; Ulatowski, John A. / Risk factors for multiple intracranial aneurysms. In: Neurosurgery. 1998 ; Vol. 43, No. 1. pp. 22-27.
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abstract = "OBJECTIVE: Risk factors that predispose to the formation of multiple intracranial aneurysms, which are present in up to 34{\%} of patients with intracranial aneurysms, are not well defined. In this study, we examined the association between known risk factors for cerebrovascular disease and presence of multiple intracranial aneurysms. METHODS: We reviewed the medical records and results of conventional angiography in all patients with a diagnosis of intracranial aneurysms admitted to the Johns Hopkins University hospital between January 1990 and June 1997. We determined the independent association between various cerebrovascular risk factors and the presence of multiple aneurysms using logistic regression analysis. RESULTS: Of 419 patients admitted with intracranial aneurysms (298 ruptured and 121 unruptured), 127 (30{\%}) had multiple intracranial aneurysms. In univariate analysis, female gender (odds ratio [OR] = 1.9; 95{\%} confidence interval [CI], 1.1-3.3) and cigarette smoking at any time (OR = 1.8; 95{\%} CI, 1.1-3.0) were significantly associated with presence of multiple aneurysms. In the multivariate analysis, cigarette smoking at any time (OR = 1.7; 95{\%} CI, 1.1- 2.8) and female gender (OR = 2.1; 95{\%} CI 1.2-3.5) remained significantly associated with multiple aneurysms. Hypertension, diabetes mellitus, and alcohol and illicit drug use were not significantly associated with presence of multiple aneurysms. CONCLUSION: Cigarette smoking and female gender seem to increase the risk for multiple aneurysms in patients predisposed to intracranial aneurysm formation. Further studies are required to investigate the mechanism underlying the association between cigarette smoking and intracranial aneurysm formation.",
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