Risk factors for Nipah virus encephalitis in Bangladesh

Joel M. Montgomery, Mohamed J. Hossain, E. Gurley, D. S. Carroll, A. Croisier, E. Bertherat, N. Asgari, P. Formenty, N. Keeler, J. Comer, M. R. Bell, K. Akram, A. R. Molla, K. Zaman, Mohamed R. Islam, K. Wagoner, J. N. Mills, P. E. Rollin, Thomas Ksiazek, R. F. Breiman

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

Original languageEnglish (US)
Pages (from-to)1526-1532
Number of pages7
JournalEmerging Infectious Diseases
Volume14
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

Nipah Virus
Bangladesh
Encephalitis
Odds Ratio
Virus Diseases
Confidence Intervals
Case-Control Studies
Disease Outbreaks
Fruit
Infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Montgomery, J. M., Hossain, M. J., Gurley, E., Carroll, D. S., Croisier, A., Bertherat, E., ... Breiman, R. F. (2008). Risk factors for Nipah virus encephalitis in Bangladesh. Emerging Infectious Diseases, 14(10), 1526-1532. https://doi.org/10.3201/eid1410.060507

Risk factors for Nipah virus encephalitis in Bangladesh. / Montgomery, Joel M.; Hossain, Mohamed J.; Gurley, E.; Carroll, D. S.; Croisier, A.; Bertherat, E.; Asgari, N.; Formenty, P.; Keeler, N.; Comer, J.; Bell, M. R.; Akram, K.; Molla, A. R.; Zaman, K.; Islam, Mohamed R.; Wagoner, K.; Mills, J. N.; Rollin, P. E.; Ksiazek, Thomas; Breiman, R. F.

In: Emerging Infectious Diseases, Vol. 14, No. 10, 10.2008, p. 1526-1532.

Research output: Contribution to journalArticle

Montgomery, JM, Hossain, MJ, Gurley, E, Carroll, DS, Croisier, A, Bertherat, E, Asgari, N, Formenty, P, Keeler, N, Comer, J, Bell, MR, Akram, K, Molla, AR, Zaman, K, Islam, MR, Wagoner, K, Mills, JN, Rollin, PE, Ksiazek, T & Breiman, RF 2008, 'Risk factors for Nipah virus encephalitis in Bangladesh', Emerging Infectious Diseases, vol. 14, no. 10, pp. 1526-1532. https://doi.org/10.3201/eid1410.060507
Montgomery JM, Hossain MJ, Gurley E, Carroll DS, Croisier A, Bertherat E et al. Risk factors for Nipah virus encephalitis in Bangladesh. Emerging Infectious Diseases. 2008 Oct;14(10):1526-1532. https://doi.org/10.3201/eid1410.060507
Montgomery, Joel M. ; Hossain, Mohamed J. ; Gurley, E. ; Carroll, D. S. ; Croisier, A. ; Bertherat, E. ; Asgari, N. ; Formenty, P. ; Keeler, N. ; Comer, J. ; Bell, M. R. ; Akram, K. ; Molla, A. R. ; Zaman, K. ; Islam, Mohamed R. ; Wagoner, K. ; Mills, J. N. ; Rollin, P. E. ; Ksiazek, Thomas ; Breiman, R. F. / Risk factors for Nipah virus encephalitis in Bangladesh. In: Emerging Infectious Diseases. 2008 ; Vol. 14, No. 10. pp. 1526-1532.
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