Risk factors for Nipah virus encephalitis in Bangladesh

Joel M. Montgomery; Mohamed J. Hossain; E. Gurley; D. S. Carroll; A. Croisier; E. Bertherat; N. Asgari; P. Formenty; N. Keeler; J. Comer; M. R. Bell; K. Akram; A. R. Molla; K. Zaman; Mohamed R. Islam; K. Wagoner; J. N. Mills; P. E. Rollin; T. G. Ksiazek; R. F. Breiman

doi:10.3201/eid1410.060507

Risk factors for Nipah virus encephalitis in Bangladesh

Joel M. Montgomery
, Mohamed J. Hossain
, E. Gurley
, D. S. Carroll
, A. Croisier
, E. Bertherat
, N. Asgari
, P. Formenty
, N. Keeler
, J. Comer
, M. R. Bell
, K. Akram
, A. R. Molla
, K. Zaman
, Mohamed R. Islam
, K. Wagoner
, J. N. Mills
, P. E. Rollin
, T. G. Ksiazek
, R. F. Breiman

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

Original language	English (US)
Pages (from-to)	1526-1532
Number of pages	7
Journal	Emerging infectious diseases
Volume	14
Issue number	10
DOIs	https://doi.org/10.3201/eid1410.060507
State	Published - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Montgomery, J. M., Hossain, M. J., Gurley, E., Carroll, D. S., Croisier, A., Bertherat, E., Asgari, N., Formenty, P., Keeler, N., Comer, J., Bell, M. R., Akram, K., Molla, A. R., Zaman, K., Islam, M. R., Wagoner, K., Mills, J. N., Rollin, P. E., Ksiazek, T. G., & Breiman, R. F. (2008). Risk factors for Nipah virus encephalitis in Bangladesh. Emerging infectious diseases, 14(10), 1526-1532. https://doi.org/10.3201/eid1410.060507

Montgomery, JM, Hossain, MJ, Gurley, E, Carroll, DS, Croisier, A, Bertherat, E, Asgari, N, Formenty, P, Keeler, N, Comer, J, Bell, MR, Akram, K, Molla, AR, Zaman, K, Islam, MR, Wagoner, K, Mills, JN, Rollin, PE, Ksiazek, TG & Breiman, RF 2008, 'Risk factors for Nipah virus encephalitis in Bangladesh', Emerging infectious diseases, vol. 14, no. 10, pp. 1526-1532. https://doi.org/10.3201/eid1410.060507

@article{e8f338b91ac446ad8ca54bc6458726c0,

title = "Risk factors for Nipah virus encephalitis in Bangladesh",

abstract = "Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95\% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83\% of cases vs. 51\% of controls, OR 8.2, 95\% CI 1.25-∞) and contact with another NiVE patient (67\% of cases vs. 9\% of controls, OR 21.4, 95\% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.",

author = "Montgomery, \{Joel M.\} and Hossain, \{Mohamed J.\} and E. Gurley and Carroll, \{D. S.\} and A. Croisier and E. Bertherat and N. Asgari and P. Formenty and N. Keeler and J. Comer and Bell, \{M. R.\} and K. Akram and Molla, \{A. R.\} and K. Zaman and Islam, \{Mohamed R.\} and K. Wagoner and Mills, \{J. N.\} and Rollin, \{P. E.\} and Ksiazek, \{T. G.\} and Breiman, \{R. F.\}",

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AU - Montgomery, Joel M.

AU - Hossain, Mohamed J.

AU - Gurley, E.

AU - Carroll, D. S.

AU - Croisier, A.

AU - Bertherat, E.

AU - Asgari, N.

AU - Formenty, P.

AU - Keeler, N.

AU - Comer, J.

AU - Bell, M. R.

AU - Akram, K.

AU - Molla, A. R.

AU - Zaman, K.

AU - Islam, Mohamed R.

AU - Wagoner, K.

AU - Mills, J. N.

AU - Rollin, P. E.

AU - Ksiazek, T. G.

AU - Breiman, R. F.

PY - 2008/10

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N2 - Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

AB - Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% CI 1.25-∞) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

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Risk factors for Nipah virus encephalitis in Bangladesh

Abstract

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