Risk factors for Nipah virus infection among abattoir workers in Singapore

Madeleine H L Chew, Paul M. Arguin, David K. Shay, Kee Tai Goh, Pierre E. Rollin, Wun Ju Shieh, Sherif R. Zaki, Paul A. Rota, Ai Ee Ling, Thomas Ksiazek, Suok Kai Chew, Larry J. Anderson

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti- Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P = .01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.

Original languageEnglish (US)
Pages (from-to)1760-1763
Number of pages4
JournalJournal of Infectious Diseases
Volume181
Issue number5
DOIs
StatePublished - 2000
Externally publishedYes

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Nipah Virus
Abattoirs
Singapore
Virus Diseases
Swine
Zoonoses
Encephalitis
Disease Outbreaks
Case-Control Studies
Pneumonia
Antibodies
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Chew, M. H. L., Arguin, P. M., Shay, D. K., Goh, K. T., Rollin, P. E., Shieh, W. J., ... Anderson, L. J. (2000). Risk factors for Nipah virus infection among abattoir workers in Singapore. Journal of Infectious Diseases, 181(5), 1760-1763. https://doi.org/10.1086/315443

Risk factors for Nipah virus infection among abattoir workers in Singapore. / Chew, Madeleine H L; Arguin, Paul M.; Shay, David K.; Goh, Kee Tai; Rollin, Pierre E.; Shieh, Wun Ju; Zaki, Sherif R.; Rota, Paul A.; Ling, Ai Ee; Ksiazek, Thomas; Chew, Suok Kai; Anderson, Larry J.

In: Journal of Infectious Diseases, Vol. 181, No. 5, 2000, p. 1760-1763.

Research output: Contribution to journalArticle

Chew, MHL, Arguin, PM, Shay, DK, Goh, KT, Rollin, PE, Shieh, WJ, Zaki, SR, Rota, PA, Ling, AE, Ksiazek, T, Chew, SK & Anderson, LJ 2000, 'Risk factors for Nipah virus infection among abattoir workers in Singapore', Journal of Infectious Diseases, vol. 181, no. 5, pp. 1760-1763. https://doi.org/10.1086/315443
Chew MHL, Arguin PM, Shay DK, Goh KT, Rollin PE, Shieh WJ et al. Risk factors for Nipah virus infection among abattoir workers in Singapore. Journal of Infectious Diseases. 2000;181(5):1760-1763. https://doi.org/10.1086/315443
Chew, Madeleine H L ; Arguin, Paul M. ; Shay, David K. ; Goh, Kee Tai ; Rollin, Pierre E. ; Shieh, Wun Ju ; Zaki, Sherif R. ; Rota, Paul A. ; Ling, Ai Ee ; Ksiazek, Thomas ; Chew, Suok Kai ; Anderson, Larry J. / Risk factors for Nipah virus infection among abattoir workers in Singapore. In: Journal of Infectious Diseases. 2000 ; Vol. 181, No. 5. pp. 1760-1763.
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