Risk of aluminum accumulation in patients with burns and ways to reduce it

G. L. Klein, David Herndon, T. C. Rutan, J. R. Barnett, N. L. Miller, A. C. Alfrey

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Severely burned patients experience a bone lesion consisting of markedly reduced bone formation and evidence of decreased resportion. The cause of the lesion may be multifactorial, but aluminum loading, which also occurs in patients with burns, has been documented to produce this type of injury in both humans and animals. To assess the risk of aluminum loading with patients with burns, we analyzed fluids, creams, and medication used in the management of acute burn injury for aluminum content. These substances were classified according to route of administration: cutaneous, enteral, or parenteral, to assess the risk of aluminum loading. Cutaneous exposure to aluminum is greatest from baths, which may provide up to 8 mg aluminum. However, the dynamics of aluminum entry into the blood via a damaged skin barrier are unclear. Enteral exposure to aluminum is no greater than daily dietary exposure. Parenteral sources of aluminum, especially 25% human serum albumin and calcium gluconate, provide the most significant risk of loading because of direct introduction of aluminum into the circulation. Substitution with a different brand of albumin and calcium chloride can reduce the parenteral aluminum load by as much as 95% and minimize any role aluminum may play in the pathogenesis of this bone lesion.

Original languageEnglish (US)
Pages (from-to)354-358
Number of pages5
JournalJournal of Burn Care and Rehabilitation
Volume15
Issue number4
DOIs
StatePublished - 1994

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Aluminum
Burns
Small Intestine
Cutaneous Administration
Calcium Gluconate
Bone and Bones
Calcium Chloride
Skin
Wounds and Injuries
Baths
Osteogenesis
Serum Albumin
Albumins

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Klein, G. L., Herndon, D., Rutan, T. C., Barnett, J. R., Miller, N. L., & Alfrey, A. C. (1994). Risk of aluminum accumulation in patients with burns and ways to reduce it. Journal of Burn Care and Rehabilitation, 15(4), 354-358. https://doi.org/10.1097/00004630-199407000-00011

Risk of aluminum accumulation in patients with burns and ways to reduce it. / Klein, G. L.; Herndon, David; Rutan, T. C.; Barnett, J. R.; Miller, N. L.; Alfrey, A. C.

In: Journal of Burn Care and Rehabilitation, Vol. 15, No. 4, 1994, p. 354-358.

Research output: Contribution to journalArticle

Klein, GL, Herndon, D, Rutan, TC, Barnett, JR, Miller, NL & Alfrey, AC 1994, 'Risk of aluminum accumulation in patients with burns and ways to reduce it', Journal of Burn Care and Rehabilitation, vol. 15, no. 4, pp. 354-358. https://doi.org/10.1097/00004630-199407000-00011
Klein, G. L. ; Herndon, David ; Rutan, T. C. ; Barnett, J. R. ; Miller, N. L. ; Alfrey, A. C. / Risk of aluminum accumulation in patients with burns and ways to reduce it. In: Journal of Burn Care and Rehabilitation. 1994 ; Vol. 15, No. 4. pp. 354-358.
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