Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia

Cande V. Ananth, Kathleen Jablonski, Leslie Myatt, James M. Roberts, Alan T.N. Tita, Kenneth J. Leveno, Uma M. Reddy, Michael W. Varner, John M. Thorp, Brian M. Mercer, Alan M. Peaceman, Susan M. Ramin, Marshall W. Carpenter, Philip Samuels, Anthony Sciscione, Jorge E. Tolosa, George Saade, Yoram Sorokin

Research output: Contribution to journalArticle

Abstract

Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

Original languageEnglish (US)
Pages (from-to)624-631
Number of pages8
JournalAmerican Journal of Perinatology
Volume36
Issue number6
DOIs
StatePublished - Jan 1 2019

Fingerprint

Placenta Diseases
Pre-Eclampsia
Siblings
Mothers
Confidence Intervals
Small for Gestational Age Infant
Live Birth
Vitamin E
Ascorbic Acid
Gestational Age
Logistic Models
Odds Ratio

Keywords

  • family history
  • inheritance
  • ischemic placental disease
  • placental abruption
  • preeclampsia
  • small for gestational age infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ananth, C. V., Jablonski, K., Myatt, L., Roberts, J. M., Tita, A. T. N., Leveno, K. J., ... Sorokin, Y. (2019). Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. American Journal of Perinatology, 36(6), 624-631. https://doi.org/10.1055/s-0038-1672177

Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. / Ananth, Cande V.; Jablonski, Kathleen; Myatt, Leslie; Roberts, James M.; Tita, Alan T.N.; Leveno, Kenneth J.; Reddy, Uma M.; Varner, Michael W.; Thorp, John M.; Mercer, Brian M.; Peaceman, Alan M.; Ramin, Susan M.; Carpenter, Marshall W.; Samuels, Philip; Sciscione, Anthony; Tolosa, Jorge E.; Saade, George; Sorokin, Yoram.

In: American Journal of Perinatology, Vol. 36, No. 6, 01.01.2019, p. 624-631.

Research output: Contribution to journalArticle

Ananth, CV, Jablonski, K, Myatt, L, Roberts, JM, Tita, ATN, Leveno, KJ, Reddy, UM, Varner, MW, Thorp, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Samuels, P, Sciscione, A, Tolosa, JE, Saade, G & Sorokin, Y 2019, 'Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia', American Journal of Perinatology, vol. 36, no. 6, pp. 624-631. https://doi.org/10.1055/s-0038-1672177
Ananth CV, Jablonski K, Myatt L, Roberts JM, Tita ATN, Leveno KJ et al. Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. American Journal of Perinatology. 2019 Jan 1;36(6):624-631. https://doi.org/10.1055/s-0038-1672177
Ananth, Cande V. ; Jablonski, Kathleen ; Myatt, Leslie ; Roberts, James M. ; Tita, Alan T.N. ; Leveno, Kenneth J. ; Reddy, Uma M. ; Varner, Michael W. ; Thorp, John M. ; Mercer, Brian M. ; Peaceman, Alan M. ; Ramin, Susan M. ; Carpenter, Marshall W. ; Samuels, Philip ; Sciscione, Anthony ; Tolosa, Jorge E. ; Saade, George ; Sorokin, Yoram. / Risk of Ischemic Placental Disease in Relation to Family History of Preeclampsia. In: American Journal of Perinatology. 2019 ; Vol. 36, No. 6. pp. 624-631.
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AU - Tita, Alan T.N.

AU - Leveno, Kenneth J.

AU - Reddy, Uma M.

AU - Varner, Michael W.

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AU - Mercer, Brian M.

AU - Peaceman, Alan M.

AU - Ramin, Susan M.

AU - Carpenter, Marshall W.

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AU - Sorokin, Yoram

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N2 - Objective To assess the risk of ischemic placental disease (IPD) including preeclampsia, small for gestational age (SGA), and abruption, in relation to preeclampsia in maternal grandmother, mother, and sister(s). Study Design We performed a secondary analysis of data from a randomized trial of vitamins C and E for preeclampsia prevention. Data on family history of preeclampsia were based on recall by the proband. The associations between family history of preeclampsia and the odds of IPD were evaluated from alternating logistic regressions. Results Of the 9,686 women who delivered nonmalformed, singleton live births, 17.1% had IPD. Probands provided data on preeclampsia in 55.5% (n = 5,374) on all three family members, 26.5% (n = 2,562) in mother and sister(s) only, and 11.6% (n = 1,125) in sister(s) only. The pairwise odds ratio (pOR) of IPD was 1.16 (95% confidence interval [CI]: 1.00-1.36) if one or more of the female relatives had preeclampsia. The pORs of preeclampsia were 1.54 (95% CI: 1.12-2.13) and 1.35 (95% CI: 1.03-1.77) if the proband's mother or sister(s) had a preeclamptic pregnancy, respectively, but no associations were seen for SGA infant or abruption. Conclusion This study suggests that IPD may share a predisposition with preeclampsia, suggesting a familial inheritance.

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