Risk of Obesity-Related Cardiometabolic Complications in Special Populations: A Crisis in Asians

Nicola Abate, Manisha Chandalia

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.

Original languageEnglish (US)
Pages (from-to)1647-1655
Number of pages9
JournalGastroenterology
Volume152
Issue number7
DOIs
StatePublished - May 1 2017

Fingerprint

Body Mass Index
Obesity
Adipose Tissue
Population
Body Fat Distribution
Body Composition
Adipocytes
Health Care Costs
Weight Gain
Insulin Resistance
Fats
Global Health

Keywords

  • Adipose Tissue
  • Cardiometabolic
  • East Asian
  • Fat Distribution
  • Insulin Resistance
  • Metabolic Syndrome
  • Obesity
  • South Asian
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Risk of Obesity-Related Cardiometabolic Complications in Special Populations : A Crisis in Asians. / Abate, Nicola; Chandalia, Manisha.

In: Gastroenterology, Vol. 152, No. 7, 01.05.2017, p. 1647-1655.

Research output: Contribution to journalArticle

Abate, Nicola ; Chandalia, Manisha. / Risk of Obesity-Related Cardiometabolic Complications in Special Populations : A Crisis in Asians. In: Gastroenterology. 2017 ; Vol. 152, No. 7. pp. 1647-1655.
@article{d8428337ebcd427b8a51f5bf5899940c,
title = "Risk of Obesity-Related Cardiometabolic Complications in Special Populations: A Crisis in Asians",
abstract = "The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.",
keywords = "Adipose Tissue, Cardiometabolic, East Asian, Fat Distribution, Insulin Resistance, Metabolic Syndrome, Obesity, South Asian, Type 2 Diabetes",
author = "Nicola Abate and Manisha Chandalia",
year = "2017",
month = "5",
day = "1",
doi = "10.1053/j.gastro.2017.01.046",
language = "English (US)",
volume = "152",
pages = "1647--1655",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - Risk of Obesity-Related Cardiometabolic Complications in Special Populations

T2 - A Crisis in Asians

AU - Abate, Nicola

AU - Chandalia, Manisha

PY - 2017/5/1

Y1 - 2017/5/1

N2 - The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.

AB - The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.

KW - Adipose Tissue

KW - Cardiometabolic

KW - East Asian

KW - Fat Distribution

KW - Insulin Resistance

KW - Metabolic Syndrome

KW - Obesity

KW - South Asian

KW - Type 2 Diabetes

UR - http://www.scopus.com/inward/record.url?scp=85018649408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018649408&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2017.01.046

DO - 10.1053/j.gastro.2017.01.046

M3 - Article

C2 - 28192110

AN - SCOPUS:85018649408

VL - 152

SP - 1647

EP - 1655

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 7

ER -