Risk of Obesity-Related Cardiometabolic Complications in Special Populations: A Crisis in Asians

Nicola Abate, Manisha Chandalia

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.

Original languageEnglish (US)
Pages (from-to)1647-1655
Number of pages9
Issue number7
StatePublished - May 2017


  • Adipose Tissue
  • Cardiometabolic
  • East Asian
  • Fat Distribution
  • Insulin Resistance
  • Metabolic Syndrome
  • Obesity
  • South Asian
  • Type 2 Diabetes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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