Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations

Gary Hankins, John C. Hauth, Thomas J. Kuehl, Yves W. Brans, F. Gary Cunningham, Wayne Pierson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To evaluate the effects of intravenously administered ritodrine hydrochloride on sodium and water metabolism, a pregnant baboon model was studied. Animals given ritodrine retained significantly more sodium (p < 0.001) and administered fluids (p < 0.002) compared with control animals. Although plasma volume did not change significantly within or between the two groups, extracellular volume increased by a mean of 1,480 ml in those given ritodrine compared with 790 ml in the control animals. There was no significant difference between animals given ritodrine and their controls regarding serial hematocrits, serum sodium, or colloid oncotic pressures. From this we conclude that the retained sodium and water was in the interstitial space. Since plasma volume was unaltered by ritodrine administration it seems unlikely that pure volume overload can explain the pulmonary edema induced by β-mimetics. Combined with the prior observation that direct pulmonary capillary membrane toxicity does not occur, the likely pathophysiology of β-agonist-induced pulmonary edema invclves left ventricular failure.

Original languageEnglish (US)
Pages (from-to)254-259
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume147
Issue number3
StatePublished - Oct 1 1983
Externally publishedYes

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Ritodrine
Papio
Sodium
Water
Plasma Volume
Pulmonary Edema
Colloids
Hematocrit
Pressure
Lung
Membranes
Serum

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Hankins, G., Hauth, J. C., Kuehl, T. J., Brans, Y. W., Cunningham, F. G., & Pierson, W. (1983). Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations. American Journal of Obstetrics and Gynecology, 147(3), 254-259.

Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations. / Hankins, Gary; Hauth, John C.; Kuehl, Thomas J.; Brans, Yves W.; Cunningham, F. Gary; Pierson, Wayne.

In: American Journal of Obstetrics and Gynecology, Vol. 147, No. 3, 01.10.1983, p. 254-259.

Research output: Contribution to journalArticle

Hankins, G, Hauth, JC, Kuehl, TJ, Brans, YW, Cunningham, FG & Pierson, W 1983, 'Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations', American Journal of Obstetrics and Gynecology, vol. 147, no. 3, pp. 254-259.
Hankins G, Hauth JC, Kuehl TJ, Brans YW, Cunningham FG, Pierson W. Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations. American Journal of Obstetrics and Gynecology. 1983 Oct 1;147(3):254-259.
Hankins, Gary ; Hauth, John C. ; Kuehl, Thomas J. ; Brans, Yves W. ; Cunningham, F. Gary ; Pierson, Wayne. / Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations. In: American Journal of Obstetrics and Gynecology. 1983 ; Vol. 147, No. 3. pp. 254-259.
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