Rocky Mountain spotted fever: A seasonal alert

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Rocky Mountain spotted fever occurs during seasonal tick activity. A history of exposure to tick-containing habitats within the 3- to 12-day incubation period is a key epidemiological factor. The signs of fever, headache, myalgia, nausea, vomiting, and anorexia at onset of infection are difficult to distinguish from those of self-limited vital infections. Rash usually appears later and, if present, progresses through a sequence of stages and distribution that are never pathognomonic. The effects of disseminated Rickettsia rickettsii infection of endothelial cells include increased vascular permeability, edema, hypovolemia, hypotension, prerenal azotemia, and, in life-threatening cases, pulmonary edema, shock, acute tubular necrosis, and meningoencephalitis. In severe cases, fluid management is a challenge. The clinical diagnosis, which is difficult, is rarely assisted by laboratory findings because antibodies are usually detected only in convalescence, and immunohistologic methods for detection of rickettsiae are unavailable in most clinics. Doxycycline is the treatment of choice except for pregnant or allergic patients, who are treated with chloramphenicol.

Original languageEnglish (US)
Pages (from-to)1111-1117
Number of pages7
JournalClinical Infectious Diseases
Volume20
Issue number5
StatePublished - 1995

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Rocky Mountain Spotted Fever
Ticks
Rickettsia Infections
Rickettsia rickettsii
Azotemia
Rickettsia
Hypovolemia
Meningoencephalitis
Doxycycline
Myalgia
Case Management
Capillary Permeability
Anorexia
Pulmonary Edema
Chloramphenicol
Infection
Exanthema
Hypotension
Nausea
Vomiting

ASJC Scopus subject areas

  • Immunology

Cite this

Rocky Mountain spotted fever : A seasonal alert. / Walker, David.

In: Clinical Infectious Diseases, Vol. 20, No. 5, 1995, p. 1111-1117.

Research output: Contribution to journalArticle

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