Rocky mountain spotted fever and deficiency in glucose-6-phosphate dehydrogenase

David Walker, H. N. Kirkman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Deficiency in glucose-6-phosphate dehydrogenase (G6PD) is a sex-linked recessive condition found principally in American black males, of whom 12% are affected. Likewise, the death rate for Rocky Mountain spotted fever (RMSF) is disproportionately high in black males. Twenty-two male patients with documented RMSF were classified as to G6PD type on the basis of activity and electrophoretic mobility of the enzyme. Severe RMSF was defined by death, acute renal failure, coma, seizures, multifocal neurologic signs, or severe coagulopathy. A binomial expansion revealed that among seven black males with severe RMSF, an overrepresentation of G6PD deficiency (three cases) was found at the P = 0.042 level of significance (figure). Clinical specimens from 15 white males with RMSF served as enzyme controls. Two fatal cases of RNSF with G6PD deficiency were fulminant.

Original languageEnglish (US)
Pages (from-to)771
Number of pages1
JournalJournal of Infectious Diseases
Volume142
Issue number5
StatePublished - 1980
Externally publishedYes

Fingerprint

Rocky Mountain Spotted Fever
Glucosephosphate Dehydrogenase Deficiency
Glucosephosphate Dehydrogenase
Enzymes
Coma
Neurologic Manifestations
Acute Kidney Injury
Seizures
Mortality

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Rocky mountain spotted fever and deficiency in glucose-6-phosphate dehydrogenase. / Walker, David; Kirkman, H. N.

In: Journal of Infectious Diseases, Vol. 142, No. 5, 1980, p. 771.

Research output: Contribution to journalArticle

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