Rocky mountain spotted fever

Hepatic lesions in childhood cases

Mark D. Jackson, Celia Kirkman, William D. Bradford, David Walker

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases..

Original languageEnglish (US)
Pages (from-to)379-388
Number of pages10
JournalFetal and Pediatric Pathology
Volume5
Issue number3-4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Rocky Mountain Spotted Fever
Kupffer Cells
Liver
Cholestasis
Leukocytosis
Vasculitis
Fluorescence Microscopy
Sex Characteristics
Blood Vessels
Neutrophils
Necrosis
Weights and Measures

Keywords

  • Immunofluorescence microscopyi
  • Light microscopy
  • Liver
  • Rickettsia rickettsii
  • Rocky mountain spotted fever

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Rocky mountain spotted fever : Hepatic lesions in childhood cases. / Jackson, Mark D.; Kirkman, Celia; Bradford, William D.; Walker, David.

In: Fetal and Pediatric Pathology, Vol. 5, No. 3-4, 1986, p. 379-388.

Research output: Contribution to journalArticle

Jackson, Mark D. ; Kirkman, Celia ; Bradford, William D. ; Walker, David. / Rocky mountain spotted fever : Hepatic lesions in childhood cases. In: Fetal and Pediatric Pathology. 1986 ; Vol. 5, No. 3-4. pp. 379-388.
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