Rocky Mountain spotted fever vaccine: A regional need

David Walker, M. R. Montenegro, B. C. Hegarty, G. R. Tringali

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward a goal of developing an effective vaccine against Rocky Mountain spotted fever.

Original languageEnglish (US)
Pages (from-to)447-449
Number of pages3
JournalSouthern Medical Journal
Volume77
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Rocky Mountain Spotted Fever
Rickettsia
Fever
Vaccines
Rickettsia rickettsii
Southeastern United States
Inactivated Vaccines
Immunity
Guinea Pigs
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Walker, D., Montenegro, M. R., Hegarty, B. C., & Tringali, G. R. (1984). Rocky Mountain spotted fever vaccine: A regional need. Southern Medical Journal, 77(4), 447-449.

Rocky Mountain spotted fever vaccine : A regional need. / Walker, David; Montenegro, M. R.; Hegarty, B. C.; Tringali, G. R.

In: Southern Medical Journal, Vol. 77, No. 4, 1984, p. 447-449.

Research output: Contribution to journalArticle

Walker, D, Montenegro, MR, Hegarty, BC & Tringali, GR 1984, 'Rocky Mountain spotted fever vaccine: A regional need', Southern Medical Journal, vol. 77, no. 4, pp. 447-449.
Walker D, Montenegro MR, Hegarty BC, Tringali GR. Rocky Mountain spotted fever vaccine: A regional need. Southern Medical Journal. 1984;77(4):447-449.
Walker, David ; Montenegro, M. R. ; Hegarty, B. C. ; Tringali, G. R. / Rocky Mountain spotted fever vaccine : A regional need. In: Southern Medical Journal. 1984 ; Vol. 77, No. 4. pp. 447-449.
@article{2e7dc85df8c449db8fe5ea6399b06f8e,
title = "Rocky Mountain spotted fever vaccine: A regional need",
abstract = "Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward a goal of developing an effective vaccine against Rocky Mountain spotted fever.",
author = "David Walker and Montenegro, {M. R.} and Hegarty, {B. C.} and Tringali, {G. R.}",
year = "1984",
language = "English (US)",
volume = "77",
pages = "447--449",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Rocky Mountain spotted fever vaccine

T2 - A regional need

AU - Walker, David

AU - Montenegro, M. R.

AU - Hegarty, B. C.

AU - Tringali, G. R.

PY - 1984

Y1 - 1984

N2 - Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward a goal of developing an effective vaccine against Rocky Mountain spotted fever.

AB - Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward a goal of developing an effective vaccine against Rocky Mountain spotted fever.

UR - http://www.scopus.com/inward/record.url?scp=0021333218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021333218&partnerID=8YFLogxK

M3 - Article

C2 - 6424239

AN - SCOPUS:0021333218

VL - 77

SP - 447

EP - 449

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 4

ER -