RODEO MRI guided laser ablation of breast cancer

Steven E. Harms, Hamid Mumtaz, Brian Hyslop, Suzanne Klimberg, Kent Westbrook, Sohelia Kourourian

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study explores the feasibility of image directed laser ablation of breast tumors as an alternative to traditional surgery. A series of 22 treatments were performed in 12 patients. The cancers were targeted with pre- and post-gadolinium enhanced RODEO breast MRI. 18 g MRI compatible needles were stereotaxically placed with RODEO breast MRI guidance. Laser ablation was implemented with a diode laser (805 nm) at 3 watts of power for about 500 seconds. The treatment was performed interactively with dynamic RODEO MRI control. The treatment zone was manifested as a hypointense zone on the dynamic images. The needle or treatment duration can be adjusted during the course of the ablation depending upon the location of the tumor and hypointense zone. In all cases correlation with conventional surgical excision with serial sectioning of the specimen was performed. PCNA stains of the treatment zone was used to confirm effective ablation and correlate the treatment zone size with the hypointense zone demonstrated on MRI. This study demonstrates the potential for RODEO breast MRI as an effective method for coordinating the interactive delivery of laser ablation in the treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3590
StatePublished - 1999
Externally publishedYes

Fingerprint

Laser Ablation
Laser ablation
Breast Cancer
breast
Magnetic resonance imaging
laser ablation
cancer
Gadolinium
Ablation
Needles
gadolinium
Tumors
needles
ablation
Tumor
tumors
Proliferating Cell Nuclear Antigen
Diode Laser
Surgery
Semiconductor lasers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Harms, S. E., Mumtaz, H., Hyslop, B., Klimberg, S., Westbrook, K., & Kourourian, S. (1999). RODEO MRI guided laser ablation of breast cancer. Proceedings of SPIE - The International Society for Optical Engineering, 3590, 484-489.

RODEO MRI guided laser ablation of breast cancer. / Harms, Steven E.; Mumtaz, Hamid; Hyslop, Brian; Klimberg, Suzanne; Westbrook, Kent; Kourourian, Sohelia.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 3590, 1999, p. 484-489.

Research output: Contribution to journalArticle

Harms, SE, Mumtaz, H, Hyslop, B, Klimberg, S, Westbrook, K & Kourourian, S 1999, 'RODEO MRI guided laser ablation of breast cancer', Proceedings of SPIE - The International Society for Optical Engineering, vol. 3590, pp. 484-489.
Harms, Steven E. ; Mumtaz, Hamid ; Hyslop, Brian ; Klimberg, Suzanne ; Westbrook, Kent ; Kourourian, Sohelia. / RODEO MRI guided laser ablation of breast cancer. In: Proceedings of SPIE - The International Society for Optical Engineering. 1999 ; Vol. 3590. pp. 484-489.
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