Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis

Pomila Singh, Bosong Dai, Hai Wu, Azar Owlia

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Colon carcinogenesis is a multistep process that involves deletions, mutations, and changes in expression of genes that regulate growth, differentiation, and apoptosis. Hyperproliferation can initiate dysplastic growth, resulting in accumulation of genetic defects and progression of colon cancer. Although genetic instability, because of inheritance of specific genetic defects, plays a dominant role in familial cancers, in the majority of sporadic cancers hyperproliferation is likely to play a permissive role in initiation and progression of the disease. Thus factors that regulate growth, differentiation, and apoptosis are likely to play an important role in colon carcinogenesis. Autocrine gastrins, insulin-like growth factor-II, transforming growth factor-α, and endocrine gastrins have been implicated in the tumorigenic potential of colon cancer cells. In this article we focus on the role of endocrine and autocrine gastrins in colon cancer and review recent advances that suggest a role of processing intermediates of gastrin in colon carcinogenesis. (C) 2000 Lippincott Williams and Wilkins, Inc.

Original languageEnglish (US)
Pages (from-to)68-77
Number of pages10
JournalCurrent Opinion in Gastroenterology
Volume16
Issue number1
DOIs
StatePublished - 2000

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Gastrins
Carcinogenesis
Colonic Neoplasms
Peptides
Colon
Growth Differentiation Factors
Apoptosis
Insulin-Like Growth Factor II
Sequence Deletion
Transforming Growth Factors
Growth
Disease Progression
Neoplasms
Gene Expression

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis. / Singh, Pomila; Dai, Bosong; Wu, Hai; Owlia, Azar.

In: Current Opinion in Gastroenterology, Vol. 16, No. 1, 2000, p. 68-77.

Research output: Contribution to journalArticle

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