Role of caffeine intake on erectile dysfunction in US men

Results from NHANES 2001-2004

David Lopez, Run Wang, Konstantinos K. Tsilidis, Huirong Zhu, Carrie R. Daniel, Arup Sinha, Steven Canfield

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED) in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED. Material and Method: Data were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted. Results: We found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95% CI, 0.37-0.89; and OR: 0.61; 95% CI, 0.38-0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01). Conclusion: Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.

Original languageEnglish (US)
Article numbere0123547
JournalPloS one
Volume10
Issue number4
DOIs
StatePublished - Apr 28 2015
Externally publishedYes

Fingerprint

National Health and Nutrition Examination Survey
Nutrition Surveys
Erectile Dysfunction
Nutrition
caffeine
Caffeine
Health
Association reactions
Coffee
Beverages
Medical problems
diet recall
Logistics
prospective studies
beverages
diabetes
Comorbidity
interviews
Sampling
Logistic Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lopez, D., Wang, R., Tsilidis, K. K., Zhu, H., Daniel, C. R., Sinha, A., & Canfield, S. (2015). Role of caffeine intake on erectile dysfunction in US men: Results from NHANES 2001-2004. PloS one, 10(4), [e0123547]. https://doi.org/10.1371/journal.pone.0123547

Role of caffeine intake on erectile dysfunction in US men : Results from NHANES 2001-2004. / Lopez, David; Wang, Run; Tsilidis, Konstantinos K.; Zhu, Huirong; Daniel, Carrie R.; Sinha, Arup; Canfield, Steven.

In: PloS one, Vol. 10, No. 4, e0123547, 28.04.2015.

Research output: Contribution to journalArticle

Lopez, D, Wang, R, Tsilidis, KK, Zhu, H, Daniel, CR, Sinha, A & Canfield, S 2015, 'Role of caffeine intake on erectile dysfunction in US men: Results from NHANES 2001-2004', PloS one, vol. 10, no. 4, e0123547. https://doi.org/10.1371/journal.pone.0123547
Lopez, David ; Wang, Run ; Tsilidis, Konstantinos K. ; Zhu, Huirong ; Daniel, Carrie R. ; Sinha, Arup ; Canfield, Steven. / Role of caffeine intake on erectile dysfunction in US men : Results from NHANES 2001-2004. In: PloS one. 2015 ; Vol. 10, No. 4.
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abstract = "Objectives: Caffeine is consumed by more than 85{\%} of adults and little is known about its role on erectile dysfunction (ED) in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED. Material and Method: Data were analyzed for 3724 men (≥20 years old) who participated in the National Health and Nutrition Examination Survey (NHANES). ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable logistic regression analyses using appropriate sampling weights were conducted. Results: We found that men in the 3rd (85-170 mg/day) and 4th (171-303 mg/day) quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day) [OR: 0.58; 95{\%} CI, 0.37-0.89; and OR: 0.61; 95{\%} CI, 0.38-0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01). Conclusion: Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.",
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