Role of Connexin/Pannexin containing channels in infectious diseases

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

In recent years it has become evident that gap junctions and hemichannels, in concert with extracellular ATP and purinergic receptors, play key roles in several physiological processes and pathological conditions. However, only recently has their importance in infectious diseases been explored, likely because early reports indicated that connexin containing channels were completely inactivated under inflammatory conditions, and therefore no further research was performed. However, recent evidence indicates that several infectious agents take advantage of these communication systems to enhance inflammation and apoptosis, as well as to participate in the infectious cycle of several pathogens. In the current review, we will discuss the role of these channels/receptors in the pathogenesis of several infectious diseases and the possibilities of generating novel therapeutic approaches to reduce or prevent these diseases.

Original languageEnglish (US)
Pages (from-to)1389-1395
Number of pages7
JournalFEBS Letters
Volume588
Issue number8
DOIs
StatePublished - Apr 17 2014
Externally publishedYes

    Fingerprint

Keywords

  • Bacteria
  • Gap junction
  • Purinergic
  • Virus

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this