Role of diet in the treatment of polycystic ovary syndrome

Crystal Douglas, Barbara A. Gower, Betty E. Darnell, Fernando Ovalle, Robert A. Oster, Ricardo Azziz

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Objective: To determine whether eucaloric diets either enriched with monounsaturated fatty acids (MUFA; 17% energy) or low in carbohydrates (Low CHO; 43% energy) would increase insulin sensitivity (Si) and decrease circulating insulin concentrations, relative to a standard diet (STD; 56% CHO, 31% fat, 16% protein), among women with polycystic ovary syndrome (PCOS). Design: Crossover. Setting: Academic research environment. Patient(s): Healthy women with PCOS not on hormonal or insulin-sensitizing therapy. Intervention(s): Subjects consumed three, 16-day, eucaloric diets, each separated by a 3-week washout period. A frequently sampled, intravenous, glucose tolerance test was administered at baseline and following each diet. Main Outcome Measure(s): Fasting glucose, insulin, the acute insulin response to glucose (AIRg), Si, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), total testosterone (T), free T, A4, total cholesterol, high-density lipoprotein cholesterol (HDL-C), tryglycerides (TG), and free fatty acids (FFA). Result(s): Fasting insulin was lower following the Low CHO diet relative to the STD diet; AIRg was lower following the Low CHO diet relative to the MUFA diet. Fasting glucose, Si, and the circulating concentrations of reproductive hormones were not significantly affected by the intervention. Conclusion(s): A moderate reduction in dietary carbohydrate reduced the fasting and postchallenge insulin concentrations among women with PCOS, which, over time, may improve reproductive/endocrine outcomes.

Original languageEnglish (US)
Pages (from-to)679-688
Number of pages10
JournalFertility and Sterility
Volume85
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Diet
Insulin
Fasting
Glucose
Therapeutics
Sexually Transmitted Diseases
Dietary Carbohydrates
Monounsaturated Fatty Acids
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Glucose Tolerance Test
Nonesterified Fatty Acids
Cross-Over Studies
HDL Cholesterol
Insulin Resistance
Testosterone
Fats
Cholesterol
Carbohydrates

Keywords

  • β-cell function
  • Hyperandrogenism
  • Insulin resistance
  • Low-carbohydrate diet
  • Monounsaturated fat
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Douglas, C., Gower, B. A., Darnell, B. E., Ovalle, F., Oster, R. A., & Azziz, R. (2006). Role of diet in the treatment of polycystic ovary syndrome. Fertility and Sterility, 85(3), 679-688. https://doi.org/10.1016/j.fertnstert.2005.08.045

Role of diet in the treatment of polycystic ovary syndrome. / Douglas, Crystal; Gower, Barbara A.; Darnell, Betty E.; Ovalle, Fernando; Oster, Robert A.; Azziz, Ricardo.

In: Fertility and Sterility, Vol. 85, No. 3, 01.03.2006, p. 679-688.

Research output: Contribution to journalArticle

Douglas, C, Gower, BA, Darnell, BE, Ovalle, F, Oster, RA & Azziz, R 2006, 'Role of diet in the treatment of polycystic ovary syndrome', Fertility and Sterility, vol. 85, no. 3, pp. 679-688. https://doi.org/10.1016/j.fertnstert.2005.08.045
Douglas, Crystal ; Gower, Barbara A. ; Darnell, Betty E. ; Ovalle, Fernando ; Oster, Robert A. ; Azziz, Ricardo. / Role of diet in the treatment of polycystic ovary syndrome. In: Fertility and Sterility. 2006 ; Vol. 85, No. 3. pp. 679-688.
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