Role of endogenous prostaglandins in regulating the tone of opossum lower esophageal sphincter in vivo

E. E. Daniel, S. Sarna, W. Waterfall, J. Crankshaw

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The role of prostaglandins in maintenance of basal myogenic tone of the lower esophageal sphincter (LES) of opossum has been studied in vivo. Intra-arterial infusion of arachidonic acid decreased LES tone, and this was inhibited by intravenous indomethacin (IDM) or intra-arterial 5,8,11,14-eicosatetraynoic acid (ETA). Alone these drugs did not reduce LES tone except transiently. In addition they did not affect relaxation of the LES to distention of a balloon located proximal to it or inhibit the "off" contractions of esophageal body and LES pressure which followed balloon deflation. Spontaneous oscillations of LES pressure were increased with IDM. Thus prostaglandin synthesis plays no essential role in maintenance of resting LES tone or in functioning of non-adrenergic inhibitory nerves in the esophagus in vivo. Endogenous inhibitory prostaglandins might reduce LES tone if synthesized in increased amounts.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalProstaglandins
Volume17
Issue number4
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Opossums
Lower Esophageal Sphincter
Prostaglandins
Balloons
Indomethacin
5,8,11,14-Eicosatetraynoic Acid
Arachidonic Acid
Maintenance
Pressure
Intra Arterial Infusions
Pharmaceutical Preparations
Esophagus

Keywords

  • Lower esophageal sphincter
  • Non-adrenergic inhibitory nerves
  • Prostaglandins
  • Sphincter tone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Role of endogenous prostaglandins in regulating the tone of opossum lower esophageal sphincter in vivo. / Daniel, E. E.; Sarna, S.; Waterfall, W.; Crankshaw, J.

In: Prostaglandins, Vol. 17, No. 4, 1979, p. 641-648.

Research output: Contribution to journalArticle

Daniel, E. E. ; Sarna, S. ; Waterfall, W. ; Crankshaw, J. / Role of endogenous prostaglandins in regulating the tone of opossum lower esophageal sphincter in vivo. In: Prostaglandins. 1979 ; Vol. 17, No. 4. pp. 641-648.
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